Ifosfamide-Induced Metabolic Encephalopathy in 2 Patients With Cutaneous T-Cell Lymphoma Successfully Treated With Methylene Blue

Ifosfamide, an alkylating agent used in cancer treatments, can cause neurotoxicity. The clinical presentation can range from mild symptoms such as acute confusion to non-convulsive seizures, severe irreversible coma, and death. The benefit of methylene blue use in treating ifosfamide-induced metabol...

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Autores principales: Vakiti, Anusha, Pilla, Ravi, Alhaj Moustafa, Muhamad, Joseph, Jacinth J., Shenoy, Aarthi G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069036/
https://www.ncbi.nlm.nih.gov/pubmed/30083561
http://dx.doi.org/10.1177/2324709618786769
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author Vakiti, Anusha
Pilla, Ravi
Alhaj Moustafa, Muhamad
Joseph, Jacinth J.
Shenoy, Aarthi G.
author_facet Vakiti, Anusha
Pilla, Ravi
Alhaj Moustafa, Muhamad
Joseph, Jacinth J.
Shenoy, Aarthi G.
author_sort Vakiti, Anusha
collection PubMed
description Ifosfamide, an alkylating agent used in cancer treatments, can cause neurotoxicity. The clinical presentation can range from mild symptoms such as acute confusion to non-convulsive seizures, severe irreversible coma, and death. The benefit of methylene blue use in treating ifosfamide-induced metabolic encephalopathy is not well established. In this article, we present 2 cases of ifosfamide-induced metabolic encephalopathy responsive to methylene blue treatment.
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spelling pubmed-60690362018-08-06 Ifosfamide-Induced Metabolic Encephalopathy in 2 Patients With Cutaneous T-Cell Lymphoma Successfully Treated With Methylene Blue Vakiti, Anusha Pilla, Ravi Alhaj Moustafa, Muhamad Joseph, Jacinth J. Shenoy, Aarthi G. J Investig Med High Impact Case Rep Case Report Ifosfamide, an alkylating agent used in cancer treatments, can cause neurotoxicity. The clinical presentation can range from mild symptoms such as acute confusion to non-convulsive seizures, severe irreversible coma, and death. The benefit of methylene blue use in treating ifosfamide-induced metabolic encephalopathy is not well established. In this article, we present 2 cases of ifosfamide-induced metabolic encephalopathy responsive to methylene blue treatment. SAGE Publications 2018-07-06 /pmc/articles/PMC6069036/ /pubmed/30083561 http://dx.doi.org/10.1177/2324709618786769 Text en © 2018 American Federation for Medical Research http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Vakiti, Anusha
Pilla, Ravi
Alhaj Moustafa, Muhamad
Joseph, Jacinth J.
Shenoy, Aarthi G.
Ifosfamide-Induced Metabolic Encephalopathy in 2 Patients With Cutaneous T-Cell Lymphoma Successfully Treated With Methylene Blue
title Ifosfamide-Induced Metabolic Encephalopathy in 2 Patients With Cutaneous T-Cell Lymphoma Successfully Treated With Methylene Blue
title_full Ifosfamide-Induced Metabolic Encephalopathy in 2 Patients With Cutaneous T-Cell Lymphoma Successfully Treated With Methylene Blue
title_fullStr Ifosfamide-Induced Metabolic Encephalopathy in 2 Patients With Cutaneous T-Cell Lymphoma Successfully Treated With Methylene Blue
title_full_unstemmed Ifosfamide-Induced Metabolic Encephalopathy in 2 Patients With Cutaneous T-Cell Lymphoma Successfully Treated With Methylene Blue
title_short Ifosfamide-Induced Metabolic Encephalopathy in 2 Patients With Cutaneous T-Cell Lymphoma Successfully Treated With Methylene Blue
title_sort ifosfamide-induced metabolic encephalopathy in 2 patients with cutaneous t-cell lymphoma successfully treated with methylene blue
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069036/
https://www.ncbi.nlm.nih.gov/pubmed/30083561
http://dx.doi.org/10.1177/2324709618786769
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