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Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance

Italy has one of the highest paediatric cancer incidence rates in Europe. We compared cancer incidence and survival rates in children (0–14 years) and adolescents (15–19 years) residing in Palermo Province (PP) with statistics derived from Italian and European surveillance systems. We included all i...

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Autores principales: Mazzucco, Walter, Cusimano, Rosanna, Mazzola, Sergio, Rudisi, Giuseppa, Zarcone, Maurizio, Marotta, Claudia, Graziano, Giorgio, D’Angelo, Paolo, Vitale, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069060/
https://www.ncbi.nlm.nih.gov/pubmed/29949937
http://dx.doi.org/10.3390/ijerph15071344
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author Mazzucco, Walter
Cusimano, Rosanna
Mazzola, Sergio
Rudisi, Giuseppa
Zarcone, Maurizio
Marotta, Claudia
Graziano, Giorgio
D’Angelo, Paolo
Vitale, Francesco
author_facet Mazzucco, Walter
Cusimano, Rosanna
Mazzola, Sergio
Rudisi, Giuseppa
Zarcone, Maurizio
Marotta, Claudia
Graziano, Giorgio
D’Angelo, Paolo
Vitale, Francesco
author_sort Mazzucco, Walter
collection PubMed
description Italy has one of the highest paediatric cancer incidence rates in Europe. We compared cancer incidence and survival rates in children (0–14 years) and adolescents (15–19 years) residing in Palermo Province (PP) with statistics derived from Italian and European surveillance systems. We included all incident cancer cases, malignant tumours and non-malignant neoplasm of central nervous system (benign and uncertain whether malignant or benign), detected in children and adolescents by the Palermo Province Cancer Registry (PPCR) between 2003 and 2012. A jointpoint regression model was applied. Annual Average Percentage Changes were calculated. The Besag–York-Mollie model was used to detect any cluster. The 5-year survival analysis was computed using Kaplan-Meier and actuarial methods. We identified 555 paediatric cancer incident cases (90% “malignant tumours”). No difference in incidence rates was highlighted between PPCR and Italy 26 registries and between PPCR and Southern Europe. No jointpoint or significant trend was identified and no cluster was detected. The 5-year overall survival didn’t differ between PP and the Italian AIRTUM pool. A borderline higher statistically significant survival was observed in age-group 1–4 when comparing PPCR to EUROCARE-5. The epidemiological surveillance documented in the PP was a paediatric cancer burden in line with Italy and southern Europe. The study supports the supplementary role of general population-based cancer registries to provide paediatric cancer surveillance of local communities.
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spelling pubmed-60690602018-08-07 Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance Mazzucco, Walter Cusimano, Rosanna Mazzola, Sergio Rudisi, Giuseppa Zarcone, Maurizio Marotta, Claudia Graziano, Giorgio D’Angelo, Paolo Vitale, Francesco Int J Environ Res Public Health Article Italy has one of the highest paediatric cancer incidence rates in Europe. We compared cancer incidence and survival rates in children (0–14 years) and adolescents (15–19 years) residing in Palermo Province (PP) with statistics derived from Italian and European surveillance systems. We included all incident cancer cases, malignant tumours and non-malignant neoplasm of central nervous system (benign and uncertain whether malignant or benign), detected in children and adolescents by the Palermo Province Cancer Registry (PPCR) between 2003 and 2012. A jointpoint regression model was applied. Annual Average Percentage Changes were calculated. The Besag–York-Mollie model was used to detect any cluster. The 5-year survival analysis was computed using Kaplan-Meier and actuarial methods. We identified 555 paediatric cancer incident cases (90% “malignant tumours”). No difference in incidence rates was highlighted between PPCR and Italy 26 registries and between PPCR and Southern Europe. No jointpoint or significant trend was identified and no cluster was detected. The 5-year overall survival didn’t differ between PP and the Italian AIRTUM pool. A borderline higher statistically significant survival was observed in age-group 1–4 when comparing PPCR to EUROCARE-5. The epidemiological surveillance documented in the PP was a paediatric cancer burden in line with Italy and southern Europe. The study supports the supplementary role of general population-based cancer registries to provide paediatric cancer surveillance of local communities. MDPI 2018-06-26 2018-07 /pmc/articles/PMC6069060/ /pubmed/29949937 http://dx.doi.org/10.3390/ijerph15071344 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mazzucco, Walter
Cusimano, Rosanna
Mazzola, Sergio
Rudisi, Giuseppa
Zarcone, Maurizio
Marotta, Claudia
Graziano, Giorgio
D’Angelo, Paolo
Vitale, Francesco
Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance
title Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance
title_full Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance
title_fullStr Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance
title_full_unstemmed Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance
title_short Childhood and Adolescence Cancers in the Palermo Province (Southern Italy): Ten Years (2003–2012) of Epidemiological Surveillance
title_sort childhood and adolescence cancers in the palermo province (southern italy): ten years (2003–2012) of epidemiological surveillance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069060/
https://www.ncbi.nlm.nih.gov/pubmed/29949937
http://dx.doi.org/10.3390/ijerph15071344
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