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Role of Carboxyl and Amine Termination on a Boron-Doped Diamond Solution Gate Field Effect Transistor (SGFET) for pH Sensing
In this paper, we report on the effect of carboxyl- and amine terminations on a boron-doped diamond surface (BDD) in relation to pH sensitivity. Carboxyl termination was achieved by anodization oxidation in Carmody buffer solution (pH 7). The carboxyl-terminated diamond surface was exposed to nitrog...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069108/ https://www.ncbi.nlm.nih.gov/pubmed/29986461 http://dx.doi.org/10.3390/s18072178 |
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author | Falina, Shaili Kawai, Sora Oi, Nobutaka Yamano, Hayate Kageura, Taisuke Suaebah, Evi Inaba, Masafumi Shintani, Yukihiro Syamsul, Mohd Kawarada, Hiroshi |
author_facet | Falina, Shaili Kawai, Sora Oi, Nobutaka Yamano, Hayate Kageura, Taisuke Suaebah, Evi Inaba, Masafumi Shintani, Yukihiro Syamsul, Mohd Kawarada, Hiroshi |
author_sort | Falina, Shaili |
collection | PubMed |
description | In this paper, we report on the effect of carboxyl- and amine terminations on a boron-doped diamond surface (BDD) in relation to pH sensitivity. Carboxyl termination was achieved by anodization oxidation in Carmody buffer solution (pH 7). The carboxyl-terminated diamond surface was exposed to nitrogen radicals to generate an amine-terminated surface. The pH sensitivity of the carboxyl- and amine-terminated surfaces was measured from pH 2 to pH 12. The pH sensitivities of the carboxyl-terminated surface at low and high pH are 45 and 3 mV/pH, respectively. The pH sensitivity after amine termination is significantly higher—the pH sensitivities at low and high pH are 65 and 24 mV/pH, respectively. We find that the negatively-charged surface properties of the carboxyl-terminated surface due to ionization of –COOH causes very low pH detection in the high pH region (pH 7–12). In the case of the amine-terminated surface, the surface properties are interchangeable in both acidic and basic solutions; therefore, we observed pH detection at both low and high pH regions. The results presented here may provide molecular-level understanding of surface properties with charged ions in pH solutions. The understanding of these surface terminations on BDD substrate may be useful to design diamond-based biosensors. |
format | Online Article Text |
id | pubmed-6069108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60691082018-08-07 Role of Carboxyl and Amine Termination on a Boron-Doped Diamond Solution Gate Field Effect Transistor (SGFET) for pH Sensing Falina, Shaili Kawai, Sora Oi, Nobutaka Yamano, Hayate Kageura, Taisuke Suaebah, Evi Inaba, Masafumi Shintani, Yukihiro Syamsul, Mohd Kawarada, Hiroshi Sensors (Basel) Article In this paper, we report on the effect of carboxyl- and amine terminations on a boron-doped diamond surface (BDD) in relation to pH sensitivity. Carboxyl termination was achieved by anodization oxidation in Carmody buffer solution (pH 7). The carboxyl-terminated diamond surface was exposed to nitrogen radicals to generate an amine-terminated surface. The pH sensitivity of the carboxyl- and amine-terminated surfaces was measured from pH 2 to pH 12. The pH sensitivities of the carboxyl-terminated surface at low and high pH are 45 and 3 mV/pH, respectively. The pH sensitivity after amine termination is significantly higher—the pH sensitivities at low and high pH are 65 and 24 mV/pH, respectively. We find that the negatively-charged surface properties of the carboxyl-terminated surface due to ionization of –COOH causes very low pH detection in the high pH region (pH 7–12). In the case of the amine-terminated surface, the surface properties are interchangeable in both acidic and basic solutions; therefore, we observed pH detection at both low and high pH regions. The results presented here may provide molecular-level understanding of surface properties with charged ions in pH solutions. The understanding of these surface terminations on BDD substrate may be useful to design diamond-based biosensors. MDPI 2018-07-06 /pmc/articles/PMC6069108/ /pubmed/29986461 http://dx.doi.org/10.3390/s18072178 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Falina, Shaili Kawai, Sora Oi, Nobutaka Yamano, Hayate Kageura, Taisuke Suaebah, Evi Inaba, Masafumi Shintani, Yukihiro Syamsul, Mohd Kawarada, Hiroshi Role of Carboxyl and Amine Termination on a Boron-Doped Diamond Solution Gate Field Effect Transistor (SGFET) for pH Sensing |
title | Role of Carboxyl and Amine Termination on a Boron-Doped Diamond Solution Gate Field Effect Transistor (SGFET) for pH Sensing |
title_full | Role of Carboxyl and Amine Termination on a Boron-Doped Diamond Solution Gate Field Effect Transistor (SGFET) for pH Sensing |
title_fullStr | Role of Carboxyl and Amine Termination on a Boron-Doped Diamond Solution Gate Field Effect Transistor (SGFET) for pH Sensing |
title_full_unstemmed | Role of Carboxyl and Amine Termination on a Boron-Doped Diamond Solution Gate Field Effect Transistor (SGFET) for pH Sensing |
title_short | Role of Carboxyl and Amine Termination on a Boron-Doped Diamond Solution Gate Field Effect Transistor (SGFET) for pH Sensing |
title_sort | role of carboxyl and amine termination on a boron-doped diamond solution gate field effect transistor (sgfet) for ph sensing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069108/ https://www.ncbi.nlm.nih.gov/pubmed/29986461 http://dx.doi.org/10.3390/s18072178 |
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