A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

Phagocytic cells such as macrophages play an important role in the host defense mechanisms mounted in response to the common human fungal pathogen Candida albicans. In vitro, C. albicans triggers macrophage NLRP3-Casp1/11-mediated pyroptosis, an inflammatory programmed cell death pathway. Here, we p...

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Detalles Bibliográficos
Autores principales: Koselny, Kristy, Mutlu, Nebibe, Minard, Annabel Y., Kumar, Anuj, Krysan, Damian J., Wellington, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069111/
https://www.ncbi.nlm.nih.gov/pubmed/30065091
http://dx.doi.org/10.1128/mBio.01204-18

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