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The Surface-Exposed PA(51-72)-Loop of the Influenza A Virus Polymerase Is Required for Viral Genome Replication

The heterotrimeric influenza A virus RNA-dependent RNA polymerase complex, composed of PB1, PB2, and PA subunits, is responsible for transcribing and replicating the viral RNA genome. The N-terminal endonuclease domain of the PA subunit performs endonucleolytic cleavage of capped host RNAs to genera...

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Detalles Bibliográficos
Autores principales:	Nilsson-Payant, Benjamin E., Sharps, Jane, Hengrung, Narin, Fodor, Ervin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069170/ https://www.ncbi.nlm.nih.gov/pubmed/29875249 http://dx.doi.org/10.1128/JVI.00687-18

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