Cargando…

Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study

Background: The human papillomavirus (HPV) vaccination program for young girls aged 11–26 years was introduced in Switzerland in 2008. The objective of this study was to evaluate the prevalence of high- and low-risk HPV in a population of undergraduate students using self-sampling for monitoring the...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeannot, Emilien, Viviano, Manuella, de Pree, Charlotte, Amadane, Mona, Kabengele, Emmanuel, Vassilakos, Pierre, Petignat, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069376/
https://www.ncbi.nlm.nih.gov/pubmed/29987255
http://dx.doi.org/10.3390/ijerph15071447
_version_ 1783343480382160896
author Jeannot, Emilien
Viviano, Manuella
de Pree, Charlotte
Amadane, Mona
Kabengele, Emmanuel
Vassilakos, Pierre
Petignat, Patrick
author_facet Jeannot, Emilien
Viviano, Manuella
de Pree, Charlotte
Amadane, Mona
Kabengele, Emmanuel
Vassilakos, Pierre
Petignat, Patrick
author_sort Jeannot, Emilien
collection PubMed
description Background: The human papillomavirus (HPV) vaccination program for young girls aged 11–26 years was introduced in Switzerland in 2008. The objective of this study was to evaluate the prevalence of high- and low-risk HPV in a population of undergraduate students using self-sampling for monitoring the HPV vaccination program’s effect. Methods: Undergraduate women aged between 18–31 years, attending the Medical School and University of Applied Sciences in Geneva, were invited to participate in the study. Included women were asked to perform vaginal self-sampling for HPV testing using a dry cotton swab. Results: A total of 409 students participated in the study—aged 18–31 years—of which 69% of the participants were vaccinated with Gardasil HPV vaccine and 31% did not received the vaccine. About HPV prevalence, 7.2% of unvaccinated women were HPV 16 or 18 positive, while 1.1% of vaccinated women were infected by HPV 16 or 18 (p < 0.01). Prevalence of HPV 6 and 11 was 8.3% in non-vaccinated women versus 2.1% in vaccinated women (p < 0.02). We observed no cross-protection for the other HPV genotypes of a low- and high-risk strain. Conclusions: Prevalence of HPV 6/11/16/18 was lower in vaccinated women versus unvaccinated women. Continued assessment of HPV vaccine effectiveness in real population is needed.
format Online
Article
Text
id pubmed-6069376
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60693762018-08-07 Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study Jeannot, Emilien Viviano, Manuella de Pree, Charlotte Amadane, Mona Kabengele, Emmanuel Vassilakos, Pierre Petignat, Patrick Int J Environ Res Public Health Article Background: The human papillomavirus (HPV) vaccination program for young girls aged 11–26 years was introduced in Switzerland in 2008. The objective of this study was to evaluate the prevalence of high- and low-risk HPV in a population of undergraduate students using self-sampling for monitoring the HPV vaccination program’s effect. Methods: Undergraduate women aged between 18–31 years, attending the Medical School and University of Applied Sciences in Geneva, were invited to participate in the study. Included women were asked to perform vaginal self-sampling for HPV testing using a dry cotton swab. Results: A total of 409 students participated in the study—aged 18–31 years—of which 69% of the participants were vaccinated with Gardasil HPV vaccine and 31% did not received the vaccine. About HPV prevalence, 7.2% of unvaccinated women were HPV 16 or 18 positive, while 1.1% of vaccinated women were infected by HPV 16 or 18 (p < 0.01). Prevalence of HPV 6 and 11 was 8.3% in non-vaccinated women versus 2.1% in vaccinated women (p < 0.02). We observed no cross-protection for the other HPV genotypes of a low- and high-risk strain. Conclusions: Prevalence of HPV 6/11/16/18 was lower in vaccinated women versus unvaccinated women. Continued assessment of HPV vaccine effectiveness in real population is needed. MDPI 2018-07-09 2018-07 /pmc/articles/PMC6069376/ /pubmed/29987255 http://dx.doi.org/10.3390/ijerph15071447 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jeannot, Emilien
Viviano, Manuella
de Pree, Charlotte
Amadane, Mona
Kabengele, Emmanuel
Vassilakos, Pierre
Petignat, Patrick
Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study
title Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study
title_full Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study
title_fullStr Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study
title_full_unstemmed Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study
title_short Prevalence of Vaccine Type Infections in Vaccinated and Non-Vaccinated Young Women: HPV-IMPACT, a Self-Sampling Study
title_sort prevalence of vaccine type infections in vaccinated and non-vaccinated young women: hpv-impact, a self-sampling study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069376/
https://www.ncbi.nlm.nih.gov/pubmed/29987255
http://dx.doi.org/10.3390/ijerph15071447
work_keys_str_mv AT jeannotemilien prevalenceofvaccinetypeinfectionsinvaccinatedandnonvaccinatedyoungwomenhpvimpactaselfsamplingstudy
AT vivianomanuella prevalenceofvaccinetypeinfectionsinvaccinatedandnonvaccinatedyoungwomenhpvimpactaselfsamplingstudy
AT depreecharlotte prevalenceofvaccinetypeinfectionsinvaccinatedandnonvaccinatedyoungwomenhpvimpactaselfsamplingstudy
AT amadanemona prevalenceofvaccinetypeinfectionsinvaccinatedandnonvaccinatedyoungwomenhpvimpactaselfsamplingstudy
AT kabengeleemmanuel prevalenceofvaccinetypeinfectionsinvaccinatedandnonvaccinatedyoungwomenhpvimpactaselfsamplingstudy
AT vassilakospierre prevalenceofvaccinetypeinfectionsinvaccinatedandnonvaccinatedyoungwomenhpvimpactaselfsamplingstudy
AT petignatpatrick prevalenceofvaccinetypeinfectionsinvaccinatedandnonvaccinatedyoungwomenhpvimpactaselfsamplingstudy