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Psoriasis Severity—A Risk Factor of Insulin Resistance Independent of Metabolic Syndrome

Background: It is still debatable whether psoriasis increases cardiovascular risk indirectly since it is associated with metabolic syndrome or is an independent cardiovascular risk factor. The aim of this study was to evaluate psoriasis severity as an independent predictor of insulin resistance (IR)...

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Autores principales: Polic, Melita Vuksic, Miskulin, Maja, Smolic, Martina, Kralik, Kristina, Miskulin, Ivan, Berkovic, Maja Cigrovski, Curcic, Ines Bilic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069377/
https://www.ncbi.nlm.nih.gov/pubmed/30011841
http://dx.doi.org/10.3390/ijerph15071486
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author Polic, Melita Vuksic
Miskulin, Maja
Smolic, Martina
Kralik, Kristina
Miskulin, Ivan
Berkovic, Maja Cigrovski
Curcic, Ines Bilic
author_facet Polic, Melita Vuksic
Miskulin, Maja
Smolic, Martina
Kralik, Kristina
Miskulin, Ivan
Berkovic, Maja Cigrovski
Curcic, Ines Bilic
author_sort Polic, Melita Vuksic
collection PubMed
description Background: It is still debatable whether psoriasis increases cardiovascular risk indirectly since it is associated with metabolic syndrome or is an independent cardiovascular risk factor. The aim of this study was to evaluate psoriasis severity as an independent predictor of insulin resistance (IR) irrespective of the presence of metabolic syndrome (MetS). Methods: This was a case control study including 128 patients stratified into two groups: patients with psoriasis and metabolic syndrome vs. patients with psoriasis and no metabolic syndrome. MetS was diagnosed according to ATP III criteria with homeostatic model assessment of insulin resistance (HOMA-IR), as well as a homeostatic model assessment of beta cell function (HOMA-β) were calculated. Results: Compared to subjects without metabolic syndrome, patients with metabolic syndrome had a significantly higher Psoriasis Area Severity Index (PASI) values (p < 0.001). The strongest correlation was established for HOMA-IR and the PASI index (p < 0.001), even after adjustment for body mass index (BMI) in regression analysis model. In patients without MetS and severe forms of disease, the HOMA-IR and HOMA-β values were significantly higher compared to mild forms of disease (p < 0.001 for all) while in subjects with MetS no difference was established for HOMA-IR or HOMA-β based on disease severity. Conclusions: Psoriasis severity is an independent risk factor of HOMA-IR, the strongest association being present in the non-MetS group, who still had preserved beta cell function suggesting direct promotion of atherosclerosis via insulin resistance depending on the disease severity, but irrespective of the presence of metabolic syndrome.
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spelling pubmed-60693772018-08-07 Psoriasis Severity—A Risk Factor of Insulin Resistance Independent of Metabolic Syndrome Polic, Melita Vuksic Miskulin, Maja Smolic, Martina Kralik, Kristina Miskulin, Ivan Berkovic, Maja Cigrovski Curcic, Ines Bilic Int J Environ Res Public Health Article Background: It is still debatable whether psoriasis increases cardiovascular risk indirectly since it is associated with metabolic syndrome or is an independent cardiovascular risk factor. The aim of this study was to evaluate psoriasis severity as an independent predictor of insulin resistance (IR) irrespective of the presence of metabolic syndrome (MetS). Methods: This was a case control study including 128 patients stratified into two groups: patients with psoriasis and metabolic syndrome vs. patients with psoriasis and no metabolic syndrome. MetS was diagnosed according to ATP III criteria with homeostatic model assessment of insulin resistance (HOMA-IR), as well as a homeostatic model assessment of beta cell function (HOMA-β) were calculated. Results: Compared to subjects without metabolic syndrome, patients with metabolic syndrome had a significantly higher Psoriasis Area Severity Index (PASI) values (p < 0.001). The strongest correlation was established for HOMA-IR and the PASI index (p < 0.001), even after adjustment for body mass index (BMI) in regression analysis model. In patients without MetS and severe forms of disease, the HOMA-IR and HOMA-β values were significantly higher compared to mild forms of disease (p < 0.001 for all) while in subjects with MetS no difference was established for HOMA-IR or HOMA-β based on disease severity. Conclusions: Psoriasis severity is an independent risk factor of HOMA-IR, the strongest association being present in the non-MetS group, who still had preserved beta cell function suggesting direct promotion of atherosclerosis via insulin resistance depending on the disease severity, but irrespective of the presence of metabolic syndrome. MDPI 2018-07-13 2018-07 /pmc/articles/PMC6069377/ /pubmed/30011841 http://dx.doi.org/10.3390/ijerph15071486 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Polic, Melita Vuksic
Miskulin, Maja
Smolic, Martina
Kralik, Kristina
Miskulin, Ivan
Berkovic, Maja Cigrovski
Curcic, Ines Bilic
Psoriasis Severity—A Risk Factor of Insulin Resistance Independent of Metabolic Syndrome
title Psoriasis Severity—A Risk Factor of Insulin Resistance Independent of Metabolic Syndrome
title_full Psoriasis Severity—A Risk Factor of Insulin Resistance Independent of Metabolic Syndrome
title_fullStr Psoriasis Severity—A Risk Factor of Insulin Resistance Independent of Metabolic Syndrome
title_full_unstemmed Psoriasis Severity—A Risk Factor of Insulin Resistance Independent of Metabolic Syndrome
title_short Psoriasis Severity—A Risk Factor of Insulin Resistance Independent of Metabolic Syndrome
title_sort psoriasis severity—a risk factor of insulin resistance independent of metabolic syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069377/
https://www.ncbi.nlm.nih.gov/pubmed/30011841
http://dx.doi.org/10.3390/ijerph15071486
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