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Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma

Basal cell carcinoma (BCC) is the most frequently occurring form of all cancers. The cost of care for BCC is one of the highest for all cancers in the Medicare population in the United States. Activation of Hedgehog (Hh) signaling pathway appears to be a key driver of BCC development. Studies involv...

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Autores principales: Noubissi, Felicite K., Yedjou, Clement G., Spiegelman, Vladimir S., Tchounwou, Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069411/
https://www.ncbi.nlm.nih.gov/pubmed/29987229
http://dx.doi.org/10.3390/ijerph15071442
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author Noubissi, Felicite K.
Yedjou, Clement G.
Spiegelman, Vladimir S.
Tchounwou, Paul B.
author_facet Noubissi, Felicite K.
Yedjou, Clement G.
Spiegelman, Vladimir S.
Tchounwou, Paul B.
author_sort Noubissi, Felicite K.
collection PubMed
description Basal cell carcinoma (BCC) is the most frequently occurring form of all cancers. The cost of care for BCC is one of the highest for all cancers in the Medicare population in the United States. Activation of Hedgehog (Hh) signaling pathway appears to be a key driver of BCC development. Studies involving mouse models have provided evidence that activation of the glioma-associated oncogene (GLI) family of transcription factors is a key step in the initiation of the tumorigenic program leading to BCC. Activation of the Wnt pathway is also observed in BCCs. In addition, the Wnt signaling pathway has been shown to be required in Hh pathway-driven development of BCC in a mouse model. Cross-talks between Wnt and Hh pathways have been observed at different levels, yet the mechanisms of these cross-talks are not fully understood. In this review, we examine the mechanism of cross-talk between Wnt and Hh signaling in BCC development and its potential relevance for treatment. Recent studies have identified insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), a direct target of the Wnt/β-catenin signaling, as the factor that binds to GLI1 mRNA and upregulates its levels and activities. This mode of regulation of GLI1 appears important in BCC tumorigenesis and could be explored in the treatment of BCCs.
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spelling pubmed-60694112018-08-07 Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma Noubissi, Felicite K. Yedjou, Clement G. Spiegelman, Vladimir S. Tchounwou, Paul B. Int J Environ Res Public Health Review Basal cell carcinoma (BCC) is the most frequently occurring form of all cancers. The cost of care for BCC is one of the highest for all cancers in the Medicare population in the United States. Activation of Hedgehog (Hh) signaling pathway appears to be a key driver of BCC development. Studies involving mouse models have provided evidence that activation of the glioma-associated oncogene (GLI) family of transcription factors is a key step in the initiation of the tumorigenic program leading to BCC. Activation of the Wnt pathway is also observed in BCCs. In addition, the Wnt signaling pathway has been shown to be required in Hh pathway-driven development of BCC in a mouse model. Cross-talks between Wnt and Hh pathways have been observed at different levels, yet the mechanisms of these cross-talks are not fully understood. In this review, we examine the mechanism of cross-talk between Wnt and Hh signaling in BCC development and its potential relevance for treatment. Recent studies have identified insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), a direct target of the Wnt/β-catenin signaling, as the factor that binds to GLI1 mRNA and upregulates its levels and activities. This mode of regulation of GLI1 appears important in BCC tumorigenesis and could be explored in the treatment of BCCs. MDPI 2018-07-09 2018-07 /pmc/articles/PMC6069411/ /pubmed/29987229 http://dx.doi.org/10.3390/ijerph15071442 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Noubissi, Felicite K.
Yedjou, Clement G.
Spiegelman, Vladimir S.
Tchounwou, Paul B.
Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma
title Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma
title_full Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma
title_fullStr Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma
title_full_unstemmed Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma
title_short Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma
title_sort cross-talk between wnt and hh signaling pathways in the pathology of basal cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069411/
https://www.ncbi.nlm.nih.gov/pubmed/29987229
http://dx.doi.org/10.3390/ijerph15071442
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