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Recommended Approaches to the Scientific Evaluation of Ecotoxicological Hazards and Risks of Endocrine-Active Substances
A SETAC Pellston Workshop® “Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)” was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on current scientific understanding, to regulators and poli...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069525/ https://www.ncbi.nlm.nih.gov/pubmed/28127947 http://dx.doi.org/10.1002/ieam.1885 |
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author | Matthiessen, Peter Ankley, Gerald T Biever, Ronald C Bjerregaard, Poul Borgert, Christopher Brugger, Kristin Blankinship, Amy Chambers, Janice Coady, Katherine K Constantine, Lisa Dang, Zhichao Denslow, Nancy D Dreier, David A Dungey, Steve Gray, L Earl Gross, Melanie Guiney, Patrick D Hecker, Markus Holbech, Henrik Iguchi, Taisen Kadlec, Sarah Karouna-Renier, Natalie K Katsiadaki, Ioanna Kawashima, Yukio Kloas, Werner Krueger, Henry Kumar, Anu Lagadic, Laurent Leopold, Annegaaike Levine, Steven L Maack, Gerd Marty, Sue Meado, James Mihaich, Ellen Odum, Jenny Ortego, Lisa Parrott, Joanne Pickford, Daniel Roberts, Mike Schaefers, Christoph Schwarz, Tamar Solomon, Keith Verslycke, Tim Weltje, Lennart Wheeler, James R Williams, Mike Wolf, Jeffrey C Yamazaki, Kunihiko |
author_facet | Matthiessen, Peter Ankley, Gerald T Biever, Ronald C Bjerregaard, Poul Borgert, Christopher Brugger, Kristin Blankinship, Amy Chambers, Janice Coady, Katherine K Constantine, Lisa Dang, Zhichao Denslow, Nancy D Dreier, David A Dungey, Steve Gray, L Earl Gross, Melanie Guiney, Patrick D Hecker, Markus Holbech, Henrik Iguchi, Taisen Kadlec, Sarah Karouna-Renier, Natalie K Katsiadaki, Ioanna Kawashima, Yukio Kloas, Werner Krueger, Henry Kumar, Anu Lagadic, Laurent Leopold, Annegaaike Levine, Steven L Maack, Gerd Marty, Sue Meado, James Mihaich, Ellen Odum, Jenny Ortego, Lisa Parrott, Joanne Pickford, Daniel Roberts, Mike Schaefers, Christoph Schwarz, Tamar Solomon, Keith Verslycke, Tim Weltje, Lennart Wheeler, James R Williams, Mike Wolf, Jeffrey C Yamazaki, Kunihiko |
author_sort | Matthiessen, Peter |
collection | PubMed |
description | A SETAC Pellston Workshop® “Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)” was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on current scientific understanding, to regulators and policy makers; the aim being to make considered, informed decisions on whether to select an ecotoxicological hazard- or a risk-based approach for regulating a given endocrinedisrupting substance (EDS) under review. The workshop additionally considered recent developments in the identification of EDS. Case studies were undertaken on 6 endocrine-active substances (EAS—not necessarily proven EDS, but substances known to interact directly with the endocrine system) that are representative of a range of perturbations of the endocrine system and considered to be data rich in relevant information at multiple biological levels of organization for 1 or more ecologically relevant taxa. The substances selected were 17α-ethinylestradiol, perchlorate, propiconazole, 17β-trenbolone, tributyltin, and vinclozolin. The 6 case studies were not comprehensive safety evaluations but provided foundations for clarifying key issues and procedures that should be considered when assessing the ecotoxicological hazards and risks of EAS and EDS. The workshop also highlighted areas of scientific uncertainty, and made specific recommendations for research and methods-development to resolve some of the identified issues. The present paper provides broad guidance for scientists in regulatory authorities, industry, and academia on issues likely to arise during the ecotoxicological hazard and risk assessment of EAS and EDS. The primary conclusion of this paper, and of the SETAC Pellston Workshop on which it is based, is that if data on environmental exposure, effects on sensitive species and life-stages, delayed effects, and effects at low concentrations are robust, initiating environmental risk assessment of EDS is scientifically sound and sufficiently reliable and protective of the environment. In the absence of such data, assessment on the basis of hazard is scientifically justified until such time as relevant new information is available. |
format | Online Article Text |
id | pubmed-6069525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-60695252018-08-01 Recommended Approaches to the Scientific Evaluation of Ecotoxicological Hazards and Risks of Endocrine-Active Substances Matthiessen, Peter Ankley, Gerald T Biever, Ronald C Bjerregaard, Poul Borgert, Christopher Brugger, Kristin Blankinship, Amy Chambers, Janice Coady, Katherine K Constantine, Lisa Dang, Zhichao Denslow, Nancy D Dreier, David A Dungey, Steve Gray, L Earl Gross, Melanie Guiney, Patrick D Hecker, Markus Holbech, Henrik Iguchi, Taisen Kadlec, Sarah Karouna-Renier, Natalie K Katsiadaki, Ioanna Kawashima, Yukio Kloas, Werner Krueger, Henry Kumar, Anu Lagadic, Laurent Leopold, Annegaaike Levine, Steven L Maack, Gerd Marty, Sue Meado, James Mihaich, Ellen Odum, Jenny Ortego, Lisa Parrott, Joanne Pickford, Daniel Roberts, Mike Schaefers, Christoph Schwarz, Tamar Solomon, Keith Verslycke, Tim Weltje, Lennart Wheeler, James R Williams, Mike Wolf, Jeffrey C Yamazaki, Kunihiko Integr Environ Assess Manag Article A SETAC Pellston Workshop® “Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)” was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on current scientific understanding, to regulators and policy makers; the aim being to make considered, informed decisions on whether to select an ecotoxicological hazard- or a risk-based approach for regulating a given endocrinedisrupting substance (EDS) under review. The workshop additionally considered recent developments in the identification of EDS. Case studies were undertaken on 6 endocrine-active substances (EAS—not necessarily proven EDS, but substances known to interact directly with the endocrine system) that are representative of a range of perturbations of the endocrine system and considered to be data rich in relevant information at multiple biological levels of organization for 1 or more ecologically relevant taxa. The substances selected were 17α-ethinylestradiol, perchlorate, propiconazole, 17β-trenbolone, tributyltin, and vinclozolin. The 6 case studies were not comprehensive safety evaluations but provided foundations for clarifying key issues and procedures that should be considered when assessing the ecotoxicological hazards and risks of EAS and EDS. The workshop also highlighted areas of scientific uncertainty, and made specific recommendations for research and methods-development to resolve some of the identified issues. The present paper provides broad guidance for scientists in regulatory authorities, industry, and academia on issues likely to arise during the ecotoxicological hazard and risk assessment of EAS and EDS. The primary conclusion of this paper, and of the SETAC Pellston Workshop on which it is based, is that if data on environmental exposure, effects on sensitive species and life-stages, delayed effects, and effects at low concentrations are robust, initiating environmental risk assessment of EDS is scientifically sound and sufficiently reliable and protective of the environment. In the absence of such data, assessment on the basis of hazard is scientifically justified until such time as relevant new information is available. 2017-01-27 2017-03 /pmc/articles/PMC6069525/ /pubmed/28127947 http://dx.doi.org/10.1002/ieam.1885 Text en This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes http//creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Matthiessen, Peter Ankley, Gerald T Biever, Ronald C Bjerregaard, Poul Borgert, Christopher Brugger, Kristin Blankinship, Amy Chambers, Janice Coady, Katherine K Constantine, Lisa Dang, Zhichao Denslow, Nancy D Dreier, David A Dungey, Steve Gray, L Earl Gross, Melanie Guiney, Patrick D Hecker, Markus Holbech, Henrik Iguchi, Taisen Kadlec, Sarah Karouna-Renier, Natalie K Katsiadaki, Ioanna Kawashima, Yukio Kloas, Werner Krueger, Henry Kumar, Anu Lagadic, Laurent Leopold, Annegaaike Levine, Steven L Maack, Gerd Marty, Sue Meado, James Mihaich, Ellen Odum, Jenny Ortego, Lisa Parrott, Joanne Pickford, Daniel Roberts, Mike Schaefers, Christoph Schwarz, Tamar Solomon, Keith Verslycke, Tim Weltje, Lennart Wheeler, James R Williams, Mike Wolf, Jeffrey C Yamazaki, Kunihiko Recommended Approaches to the Scientific Evaluation of Ecotoxicological Hazards and Risks of Endocrine-Active Substances |
title | Recommended Approaches to the Scientific Evaluation of Ecotoxicological Hazards and Risks of Endocrine-Active Substances |
title_full | Recommended Approaches to the Scientific Evaluation of Ecotoxicological Hazards and Risks of Endocrine-Active Substances |
title_fullStr | Recommended Approaches to the Scientific Evaluation of Ecotoxicological Hazards and Risks of Endocrine-Active Substances |
title_full_unstemmed | Recommended Approaches to the Scientific Evaluation of Ecotoxicological Hazards and Risks of Endocrine-Active Substances |
title_short | Recommended Approaches to the Scientific Evaluation of Ecotoxicological Hazards and Risks of Endocrine-Active Substances |
title_sort | recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069525/ https://www.ncbi.nlm.nih.gov/pubmed/28127947 http://dx.doi.org/10.1002/ieam.1885 |
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