Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas

BACKGROUND: Alteration of DNA methylation of tumor suppressor genes (TSGs) is one of the most consistent epigenetic changes in human cancers. DNMTs play several important roles in DNA methylation and development of cancers. Regarding DNMTs protein expressions, little is known about the clinical sign...

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Detalles Bibliográficos
Autores principales: Ma, Hou-Shi, Wang, Elaine Lu, Xu, Wen-Fei, Yamada, Shozo, Yoshimoto, Katsuhiko, Qian, Zhi Rong, Shi, Long, Liu, Li-Li, Li, Xu-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Lab/In Vitro Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069575/
https://www.ncbi.nlm.nih.gov/pubmed/30002361
http://dx.doi.org/10.12659/MSM.910608

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