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Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent
The wide use of disinfectants has prompted resistance from the microbiome which will in turn reduce the bactericidal effect of disinfectants. Hence, glutaraldehyde (GA) and didecyldimethylammonium bromide (DDAB) were used to develop a combination disinfectant with high stability and antimicrobial ef...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069694/ https://www.ncbi.nlm.nih.gov/pubmed/30079353 http://dx.doi.org/10.1155/2018/9814209 |
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author | Lin, Wenshu Niu, Bing Yi, Jialin Deng, Zhirui Song, Jiang Chen, Qin |
author_facet | Lin, Wenshu Niu, Bing Yi, Jialin Deng, Zhirui Song, Jiang Chen, Qin |
author_sort | Lin, Wenshu |
collection | PubMed |
description | The wide use of disinfectants has prompted resistance from the microbiome which will in turn reduce the bactericidal effect of disinfectants. Hence, glutaraldehyde (GA) and didecyldimethylammonium bromide (DDAB) were used to develop a combination disinfectant with high stability and antimicrobial effects, which was named GA-DDAB combination disinfectant (GD). The bactericidal mechanism against Escherichia coli was studied in our earlier work. In this study, we focused on GD's bactericidal efficacy in both the laboratory and environment, the genetic toxicity to mouse lymphoma L5178Y TK(+/−) cells, acute peroral toxicity in mice, and its metal corrosion properties with a view to providing theoretical support for developing a high-efficiency, low toxicity, and weakly corrosive disinfectant for general use. |
format | Online Article Text |
id | pubmed-6069694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60696942018-08-05 Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent Lin, Wenshu Niu, Bing Yi, Jialin Deng, Zhirui Song, Jiang Chen, Qin Biomed Res Int Research Article The wide use of disinfectants has prompted resistance from the microbiome which will in turn reduce the bactericidal effect of disinfectants. Hence, glutaraldehyde (GA) and didecyldimethylammonium bromide (DDAB) were used to develop a combination disinfectant with high stability and antimicrobial effects, which was named GA-DDAB combination disinfectant (GD). The bactericidal mechanism against Escherichia coli was studied in our earlier work. In this study, we focused on GD's bactericidal efficacy in both the laboratory and environment, the genetic toxicity to mouse lymphoma L5178Y TK(+/−) cells, acute peroral toxicity in mice, and its metal corrosion properties with a view to providing theoretical support for developing a high-efficiency, low toxicity, and weakly corrosive disinfectant for general use. Hindawi 2018-07-09 /pmc/articles/PMC6069694/ /pubmed/30079353 http://dx.doi.org/10.1155/2018/9814209 Text en Copyright © 2018 Wenshu Lin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lin, Wenshu Niu, Bing Yi, Jialin Deng, Zhirui Song, Jiang Chen, Qin Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent |
title | Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent |
title_full | Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent |
title_fullStr | Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent |
title_full_unstemmed | Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent |
title_short | Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent |
title_sort | toxicity and metal corrosion of glutaraldehyde-didecyldimethylammonium bromide as a disinfectant agent |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069694/ https://www.ncbi.nlm.nih.gov/pubmed/30079353 http://dx.doi.org/10.1155/2018/9814209 |
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