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Current overview and treatment of mantle cell lymphoma

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma with historically poor long-term survival compared with other B-cell malignancies. Treatment strategies for this disease are variable and dependent on symptoms and patient fitness. Despite recent advances, MCL remains incurable and patients...

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Detalles Bibliográficos
Autores principales: Schieber, Michael, Gordon, Leo I., Karmali, Reem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069726/
https://www.ncbi.nlm.nih.gov/pubmed/30109020
http://dx.doi.org/10.12688/f1000research.14122.1
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author Schieber, Michael
Gordon, Leo I.
Karmali, Reem
author_facet Schieber, Michael
Gordon, Leo I.
Karmali, Reem
author_sort Schieber, Michael
collection PubMed
description Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma with historically poor long-term survival compared with other B-cell malignancies. Treatment strategies for this disease are variable and dependent on symptoms and patient fitness. Despite recent advances, MCL remains incurable and patients with high-risk disease have particularly poor outcomes. This review focuses on recent developments that enhance our understanding of the biology of MCL and new treatment approaches that have led to substantial improvements in clinical outcomes. We will outline induction immuno-chemotherapy and maintenance strategies in transplant-eligible patients. In addition, effective strategies for patients unfit for intensive induction will be discussed, with a particular focus on novel molecular therapies with activity in MCL. Lastly, a number of ongoing clinical trials will be presented; the data from these trials are anticipated to redefine standards of care in the near future.
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spelling pubmed-60697262018-08-13 Current overview and treatment of mantle cell lymphoma Schieber, Michael Gordon, Leo I. Karmali, Reem F1000Res Review Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma with historically poor long-term survival compared with other B-cell malignancies. Treatment strategies for this disease are variable and dependent on symptoms and patient fitness. Despite recent advances, MCL remains incurable and patients with high-risk disease have particularly poor outcomes. This review focuses on recent developments that enhance our understanding of the biology of MCL and new treatment approaches that have led to substantial improvements in clinical outcomes. We will outline induction immuno-chemotherapy and maintenance strategies in transplant-eligible patients. In addition, effective strategies for patients unfit for intensive induction will be discussed, with a particular focus on novel molecular therapies with activity in MCL. Lastly, a number of ongoing clinical trials will be presented; the data from these trials are anticipated to redefine standards of care in the near future. F1000 Research Limited 2018-07-25 /pmc/articles/PMC6069726/ /pubmed/30109020 http://dx.doi.org/10.12688/f1000research.14122.1 Text en Copyright: © 2018 Schieber M et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Schieber, Michael
Gordon, Leo I.
Karmali, Reem
Current overview and treatment of mantle cell lymphoma
title Current overview and treatment of mantle cell lymphoma
title_full Current overview and treatment of mantle cell lymphoma
title_fullStr Current overview and treatment of mantle cell lymphoma
title_full_unstemmed Current overview and treatment of mantle cell lymphoma
title_short Current overview and treatment of mantle cell lymphoma
title_sort current overview and treatment of mantle cell lymphoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069726/
https://www.ncbi.nlm.nih.gov/pubmed/30109020
http://dx.doi.org/10.12688/f1000research.14122.1
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