Cargando…
Maternal central obesity and birth size: a Mendelian randomization analysis
BACKGROUND: Observational studies have illustrated that maternal central obesity is associated with birth size, including of birth weight, birth length and head circumference, but the causal nature of these associations remains unclear. Our study aimed to test the causal effect of maternal central o...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069873/ https://www.ncbi.nlm.nih.gov/pubmed/30064420 http://dx.doi.org/10.1186/s12944-018-0831-4 |
_version_ | 1783343589434064896 |
---|---|
author | Geng, Ting-Ting Huang, Tao |
author_facet | Geng, Ting-Ting Huang, Tao |
author_sort | Geng, Ting-Ting |
collection | PubMed |
description | BACKGROUND: Observational studies have illustrated that maternal central obesity is associated with birth size, including of birth weight, birth length and head circumference, but the causal nature of these associations remains unclear. Our study aimed to test the causal effect of maternal central obesity on birth size and puberty height growth using a Mendelian randomization (MR) analysis. METHODS: We performed two-sample MR using summary-level genome-wide public data. Thirty-five single nucleotide polymorphisms (SNPs), 25 SNPs and 41 SNPs were selected as instrumental variables for waist-to-hip ratio adjusted for BMI, waist circumference adjusted for BMI and hip circumference adjusted for BMI, respectively to test the causal effects of maternal central obesity on birth size and puberty height using an inverse-variance-weighted approach. RESULTS: In this MR analysis, we found no evidence of a causal association between waist circumference or waist-to-hip ratio and the outcomes. However, we observed that one standard deviation (SD) increase in hip circumference (HIP) was associated with a 0.392 SD increase in birth length (p = 1.1 × 10(− 6)) and a 0.168 SD increase in birth weight (p = 7.1 × 10(− 5)), respectively at the Bonferroni-adjusted level of significance. In addition, higher genetically predicted maternal HIP was strongly associated with the puberty heights (0.835 SD, p = 8.4 × 10(− 10)). However, HIP was not associated with head circumference (p = 0.172). CONCLUSIONS: A genetic predisposition to higher maternal HIP was causally associated with larger offspring birth size independent of maternal BMI. However, we found no evidence of a causal association between maternal waist circumference, waist-to-hip ratio and birth size. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12944-018-0831-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6069873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60698732018-08-06 Maternal central obesity and birth size: a Mendelian randomization analysis Geng, Ting-Ting Huang, Tao Lipids Health Dis Research BACKGROUND: Observational studies have illustrated that maternal central obesity is associated with birth size, including of birth weight, birth length and head circumference, but the causal nature of these associations remains unclear. Our study aimed to test the causal effect of maternal central obesity on birth size and puberty height growth using a Mendelian randomization (MR) analysis. METHODS: We performed two-sample MR using summary-level genome-wide public data. Thirty-five single nucleotide polymorphisms (SNPs), 25 SNPs and 41 SNPs were selected as instrumental variables for waist-to-hip ratio adjusted for BMI, waist circumference adjusted for BMI and hip circumference adjusted for BMI, respectively to test the causal effects of maternal central obesity on birth size and puberty height using an inverse-variance-weighted approach. RESULTS: In this MR analysis, we found no evidence of a causal association between waist circumference or waist-to-hip ratio and the outcomes. However, we observed that one standard deviation (SD) increase in hip circumference (HIP) was associated with a 0.392 SD increase in birth length (p = 1.1 × 10(− 6)) and a 0.168 SD increase in birth weight (p = 7.1 × 10(− 5)), respectively at the Bonferroni-adjusted level of significance. In addition, higher genetically predicted maternal HIP was strongly associated with the puberty heights (0.835 SD, p = 8.4 × 10(− 10)). However, HIP was not associated with head circumference (p = 0.172). CONCLUSIONS: A genetic predisposition to higher maternal HIP was causally associated with larger offspring birth size independent of maternal BMI. However, we found no evidence of a causal association between maternal waist circumference, waist-to-hip ratio and birth size. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12944-018-0831-4) contains supplementary material, which is available to authorized users. BioMed Central 2018-07-31 /pmc/articles/PMC6069873/ /pubmed/30064420 http://dx.doi.org/10.1186/s12944-018-0831-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Geng, Ting-Ting Huang, Tao Maternal central obesity and birth size: a Mendelian randomization analysis |
title | Maternal central obesity and birth size: a Mendelian randomization analysis |
title_full | Maternal central obesity and birth size: a Mendelian randomization analysis |
title_fullStr | Maternal central obesity and birth size: a Mendelian randomization analysis |
title_full_unstemmed | Maternal central obesity and birth size: a Mendelian randomization analysis |
title_short | Maternal central obesity and birth size: a Mendelian randomization analysis |
title_sort | maternal central obesity and birth size: a mendelian randomization analysis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069873/ https://www.ncbi.nlm.nih.gov/pubmed/30064420 http://dx.doi.org/10.1186/s12944-018-0831-4 |
work_keys_str_mv | AT gengtingting maternalcentralobesityandbirthsizeamendelianrandomizationanalysis AT huangtao maternalcentralobesityandbirthsizeamendelianrandomizationanalysis |