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Glutamatergic Signaling Drives Ketamine-Mediated Response in Depression: Evidence from Dynamic Causal Modeling

BACKGROUND: The glutamatergic modulator ketamine has rapid antidepressant effects in individuals with major depressive disorder and bipolar depression. Thus, modulating glutamatergic transmission may be critical to effectively treating depression, though the mechanisms by which this occurs are not f...

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Detalles Bibliográficos
Autores principales: Gilbert, Jessica R, Yarrington, Julia S, Wills, Kathleen E, Nugent, Allison C, Zarate, Carlos A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070027/
https://www.ncbi.nlm.nih.gov/pubmed/29668918
http://dx.doi.org/10.1093/ijnp/pyy041