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Levels of Serum Brain-Derived Neurotropic Factor in Individuals at Ultra-High Risk for Psychosis—Findings from the Longitudinal Youth at Risk Study (LYRIKS)
BACKGROUND: Identifying biomarkers to enrich prognostication and risk predictions in individuals at high risk of developing psychosis will enable stratified early intervention efforts. Brain-derived neurotrophic factor has been widely studied in schizophrenia and in first-episode psychosis with prom...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070044/ https://www.ncbi.nlm.nih.gov/pubmed/29584866 http://dx.doi.org/10.1093/ijnp/pyy036 |
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author | Yee, Jie Yin Lee, Tih-Shih Lee, Jimmy |
author_facet | Yee, Jie Yin Lee, Tih-Shih Lee, Jimmy |
author_sort | Yee, Jie Yin |
collection | PubMed |
description | BACKGROUND: Identifying biomarkers to enrich prognostication and risk predictions in individuals at high risk of developing psychosis will enable stratified early intervention efforts. Brain-derived neurotrophic factor has been widely studied in schizophrenia and in first-episode psychosis with promising results. The aim of this study was to examine the levels of serum brain-derived neurotrophic factor between healthy controls and individuals with ultra-high risk of psychosis. METHODS: A sample of 106 healthy controls and 105 ultra-high risk of psychosis individuals from the Longitudinal Youth at Risk Study was included in this study. Ultra-high risk of psychosis status was determined using the Comprehensive Assessment of At-Risk Mental State at recruitment. Calgary Depression Scale for Schizophrenia was used to assess the severity of depression. All participants were followed up for 2 years, and ultra-high risk of psychosis remitters were defined by ultra-high risk of psychosis individuals who no longer fulfilled Comprehensive Assessment of At-Risk Mental State criteria at the end of the study period. Levels of brain-derived neurotrophic factor were measured in the serum by enzyme-linked immunosorbent assay method. RESULTS: The ultra-high risk of psychosis group had significantly higher baseline levels of serum brain-derived neurotrophic factor compared with the control group (3.7 vs 3.3 ng/mL, P=.018). However, baseline levels of serum brain-derived neurotrophic factor did not predict the development of psychosis (OR=0.64, CI=0.40–1.02) or remission (OR=0.83, CI=0.60–1.15) from ultra-high risk of psychosis status. CONCLUSION: Findings from our study did not support a role for serum brain-derived neurotrophic factor in predicting outcomes in ultra-high risk of psychosis individuals. However, the finding of higher levels of serum brain-derived neurotrophic factor in ultra-high risk of psychosis individuals deserves further study. |
format | Online Article Text |
id | pubmed-6070044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60700442018-08-08 Levels of Serum Brain-Derived Neurotropic Factor in Individuals at Ultra-High Risk for Psychosis—Findings from the Longitudinal Youth at Risk Study (LYRIKS) Yee, Jie Yin Lee, Tih-Shih Lee, Jimmy Int J Neuropsychopharmacol Regular Research Articles BACKGROUND: Identifying biomarkers to enrich prognostication and risk predictions in individuals at high risk of developing psychosis will enable stratified early intervention efforts. Brain-derived neurotrophic factor has been widely studied in schizophrenia and in first-episode psychosis with promising results. The aim of this study was to examine the levels of serum brain-derived neurotrophic factor between healthy controls and individuals with ultra-high risk of psychosis. METHODS: A sample of 106 healthy controls and 105 ultra-high risk of psychosis individuals from the Longitudinal Youth at Risk Study was included in this study. Ultra-high risk of psychosis status was determined using the Comprehensive Assessment of At-Risk Mental State at recruitment. Calgary Depression Scale for Schizophrenia was used to assess the severity of depression. All participants were followed up for 2 years, and ultra-high risk of psychosis remitters were defined by ultra-high risk of psychosis individuals who no longer fulfilled Comprehensive Assessment of At-Risk Mental State criteria at the end of the study period. Levels of brain-derived neurotrophic factor were measured in the serum by enzyme-linked immunosorbent assay method. RESULTS: The ultra-high risk of psychosis group had significantly higher baseline levels of serum brain-derived neurotrophic factor compared with the control group (3.7 vs 3.3 ng/mL, P=.018). However, baseline levels of serum brain-derived neurotrophic factor did not predict the development of psychosis (OR=0.64, CI=0.40–1.02) or remission (OR=0.83, CI=0.60–1.15) from ultra-high risk of psychosis status. CONCLUSION: Findings from our study did not support a role for serum brain-derived neurotrophic factor in predicting outcomes in ultra-high risk of psychosis individuals. However, the finding of higher levels of serum brain-derived neurotrophic factor in ultra-high risk of psychosis individuals deserves further study. Oxford University Press 2018-03-23 /pmc/articles/PMC6070044/ /pubmed/29584866 http://dx.doi.org/10.1093/ijnp/pyy036 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Regular Research Articles Yee, Jie Yin Lee, Tih-Shih Lee, Jimmy Levels of Serum Brain-Derived Neurotropic Factor in Individuals at Ultra-High Risk for Psychosis—Findings from the Longitudinal Youth at Risk Study (LYRIKS) |
title | Levels of Serum Brain-Derived Neurotropic Factor in Individuals at Ultra-High Risk for Psychosis—Findings from the Longitudinal Youth at Risk Study (LYRIKS) |
title_full | Levels of Serum Brain-Derived Neurotropic Factor in Individuals at Ultra-High Risk for Psychosis—Findings from the Longitudinal Youth at Risk Study (LYRIKS) |
title_fullStr | Levels of Serum Brain-Derived Neurotropic Factor in Individuals at Ultra-High Risk for Psychosis—Findings from the Longitudinal Youth at Risk Study (LYRIKS) |
title_full_unstemmed | Levels of Serum Brain-Derived Neurotropic Factor in Individuals at Ultra-High Risk for Psychosis—Findings from the Longitudinal Youth at Risk Study (LYRIKS) |
title_short | Levels of Serum Brain-Derived Neurotropic Factor in Individuals at Ultra-High Risk for Psychosis—Findings from the Longitudinal Youth at Risk Study (LYRIKS) |
title_sort | levels of serum brain-derived neurotropic factor in individuals at ultra-high risk for psychosis—findings from the longitudinal youth at risk study (lyriks) |
topic | Regular Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070044/ https://www.ncbi.nlm.nih.gov/pubmed/29584866 http://dx.doi.org/10.1093/ijnp/pyy036 |
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