The Friday evening case of acute kidney injury: a crystal dilemma

We report a case of acute kidney injury (AKI) induced by amoxycillin crystalluria suggested by massive amounts of urinary crystals of unusual morphology. This hypothesis was further reinforced by a particular solubility pattern when the urine sample was exposed to various temperatures, alkali, acids...

Descripción completa

Detalles Bibliográficos
Autores principales: Guzzo, Gabriella, Fogazzi, Giovanni B, Cariello, Cristina, Barberini, Luc-Emmanuel, Petignat, Pierre-Auguste, Teta, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acute Kidney Injury
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070073/
https://www.ncbi.nlm.nih.gov/pubmed/30094007
http://dx.doi.org/10.1093/ckj/sfx114
_version_ 1783343616898367488
author Guzzo, Gabriella
Fogazzi, Giovanni B
Cariello, Cristina
Barberini, Luc-Emmanuel
Petignat, Pierre-Auguste
Teta, Daniel
author_facet Guzzo, Gabriella
Fogazzi, Giovanni B
Cariello, Cristina
Barberini, Luc-Emmanuel
Petignat, Pierre-Auguste
Teta, Daniel
author_sort Guzzo, Gabriella
collection PubMed
description We report a case of acute kidney injury (AKI) induced by amoxycillin crystalluria suggested by massive amounts of urinary crystals of unusual morphology. This hypothesis was further reinforced by a particular solubility pattern when the urine sample was exposed to various temperatures, alkali, acids and alcohol. We therefore suspended amoxycillin, which produced a rapid and complete recovery of kidney function. Infrared spectroscopy later confirmed the amoxycillin composition of the crystals. Since infrared spectroscopy is not easily available, we propose that these solubility tests of urinary crystals be used as a first-step investigation when amoxycillin crystalluria is suspected.
format Online
Article
Text
id pubmed-6070073
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-60700732018-08-09 The Friday evening case of acute kidney injury: a crystal dilemma Guzzo, Gabriella Fogazzi, Giovanni B Cariello, Cristina Barberini, Luc-Emmanuel Petignat, Pierre-Auguste Teta, Daniel Clin Kidney J Acute Kidney Injury We report a case of acute kidney injury (AKI) induced by amoxycillin crystalluria suggested by massive amounts of urinary crystals of unusual morphology. This hypothesis was further reinforced by a particular solubility pattern when the urine sample was exposed to various temperatures, alkali, acids and alcohol. We therefore suspended amoxycillin, which produced a rapid and complete recovery of kidney function. Infrared spectroscopy later confirmed the amoxycillin composition of the crystals. Since infrared spectroscopy is not easily available, we propose that these solubility tests of urinary crystals be used as a first-step investigation when amoxycillin crystalluria is suspected. Oxford University Press 2018-08 2017-10-18 /pmc/articles/PMC6070073/ /pubmed/30094007 http://dx.doi.org/10.1093/ckj/sfx114 Text en © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Acute Kidney Injury
Guzzo, Gabriella
Fogazzi, Giovanni B
Cariello, Cristina
Barberini, Luc-Emmanuel
Petignat, Pierre-Auguste
Teta, Daniel
The Friday evening case of acute kidney injury: a crystal dilemma
title The Friday evening case of acute kidney injury: a crystal dilemma
title_full The Friday evening case of acute kidney injury: a crystal dilemma
title_fullStr The Friday evening case of acute kidney injury: a crystal dilemma
title_full_unstemmed The Friday evening case of acute kidney injury: a crystal dilemma
title_short The Friday evening case of acute kidney injury: a crystal dilemma
title_sort friday evening case of acute kidney injury: a crystal dilemma
topic Acute Kidney Injury
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070073/
https://www.ncbi.nlm.nih.gov/pubmed/30094007
http://dx.doi.org/10.1093/ckj/sfx114
work_keys_str_mv AT guzzogabriella thefridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT fogazzigiovannib thefridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT cariellocristina thefridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT barberinilucemmanuel thefridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT petignatpierreauguste thefridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT tetadaniel thefridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT guzzogabriella fridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT fogazzigiovannib fridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT cariellocristina fridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT barberinilucemmanuel fridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT petignatpierreauguste fridayeveningcaseofacutekidneyinjuryacrystaldilemma
AT tetadaniel fridayeveningcaseofacutekidneyinjuryacrystaldilemma

Ejemplares similares