Cargando…

NorUDCA promotes degradation of α1-antitrypsin mutant Z protein by inducing autophagy through AMPK/ULK1 pathway

Alpha-1 Antitrypsin (α1AT) Deficiency is a genetic disease in which accumulation of α1AT mutant Z (α1ATZ) protein in the ER of hepatocytes causes chronic liver injury, liver fibrosis, and hepatocellular carcinoma. No effective medical therapy is currently available for the disease. We previously fou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Youcai, Blomenkamp, Keith S., Fickert, Peter, Trauner, Michael, Teckman, Jeffrey H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070232/ https://www.ncbi.nlm.nih.gov/pubmed/30067827 http://dx.doi.org/10.1371/journal.pone.0200897

Ejemplares similares

Differential effects of norUDCA and UDCA in obstructive cholestasis in mice
por: Fickert, Peter, et al.
Publicado: (2013)

Evidence for functional selectivity in TUDC- and norUDCA-induced signal transduction via α(5)β(1) integrin towards choleresis
por: Bonus, Michele, et al.
Publicado: (2020)

The Association of AMPK with ULK1 Regulates Autophagy
por: Lee, Jong Woo, et al.
Publicado: (2010)

Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury
por: Stearns, Kyle, et al.
Publicado: (2021)

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
por: Dite, Toby A., et al.
Publicado: (2017)

Activation of the c‐Jun N‐terminal kinase pathway aggravates proteotoxicity of hepatic mutant Z alpha1‐antitrypsin
por: Pastore, Nunzia, et al.
Publicado: (2017)

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
por: Wang, Jiwei, et al.
Publicado: (2016)

Fine-tuning of AMPK–ULK1–mTORC1 regulatory triangle is crucial for autophagy oscillation
por: Holczer, Marianna, et al.
Publicado: (2020)

Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection
por: Fan, Xue-Yu, et al.
Publicado: (2015)

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Osteogenic Differentiation by Modulating AMPK/ULK1‐Dependent Autophagy
por: Li, Zheng, et al.
Publicado: (2019)

Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth
por: Liu, Jing, et al.
Publicado: (2019)

STAT3 suppresses the AMPKα/ULK1‐dependent induction of autophagy in glioblastoma cells
por: Bhattacharya, Sujoy, et al.
Publicado: (2022)

SLC45A4 promotes glycolysis and prevents AMPK/ULK1‐induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma
por: Chen, Wenying, et al.
Publicado: (2021)

Glyceric Prodrug of Ursodeoxycholic Acid (UDCA): Novozym 435-Catalyzed Synthesis of UDCA-Monoglyceride
por: Zappaterra, Federico, et al.
Publicado: (2021)

Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway
por: Yuan, Jie, et al.
Publicado: (2018)

AMPK/Ulk1-dependent autophagy as a key mTOR regulator in the context of cell pluripotency
por: Suvorova, Irina I., et al.
Publicado: (2019)

Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway
por: Ma, Teng, et al.
Publicado: (2022)

Liver disease with unknown etiology – have you ruled out alpha-1 antitrypsin deficiency?
por: Patel, Dhiren, et al.
Publicado: (2021)

Salvia chinensia Benth induces autophagy in esophageal cancer cells via AMPK/ULK1 signaling pathway
por: Jia, Lei, et al.
Publicado: (2022)

The mammalian ULK1 complex and autophagy initiation
por: Zachari, Maria, et al.
Publicado: (2017)

Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling
por: Lin, Chenchu, et al.
Publicado: (2021)

Geniposide Improves Diabetic Nephropathy by Enhancing ULK1-Mediated Autophagy and Reducing Oxidative Stress through AMPK Activation
por: Dusabimana, Theodomir, et al.
Publicado: (2021)

Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma
por: Pan, Zhen, et al.
Publicado: (2023)

Appropriateness of Newborn Screening for α1-Antitrypsin Deficiency
por: Teckman, Jeffrey, et al.
Publicado: (2014)

PiZ Mouse Liver Accumulates Polyubiquitin Conjugates That Associate with Catalytically Active 26S Proteasomes
por: Haddock, Christopher J., et al.
Publicado: (2014)

ULK1 cycling: The ups and downs of the autophagy response
por: Zhao, Yan G., et al.
Publicado: (2016)

Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK/ULK1/autophagy pathway
por: Xiong, Wei, et al.
Publicado: (2021)

Prototheca bovis induces autophagy in bovine mammary epithelial cells via the HIF-1α and AMPKα/ULK1 pathway
por: Zhao, Wenpeng, et al.
Publicado: (2022)

Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
por: Ahwazi, Danial, et al.
Publicado: (2021)

Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function
por: Harris, Matthew P., et al.
Publicado: (2022)

Lipopolysaccharide-Induced Dephosphorylation of AMPK-Activated Protein Kinase Potentiates Inflammatory Injury via Repression of ULK1-Dependent Autophagy
por: Fan, Kerui, et al.
Publicado: (2018)

Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy
por: Liu, Buhui, et al.
Publicado: (2018)

Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis
por: Che, Lixiao, et al.
Publicado: (2019)

Tangshen Decoction Enhances Podocytes Autophagy to Relieve Diabetic Nephropathy through Modulation of p-AMPK/p-ULK1 Signaling
por: Yan, Ling, et al.
Publicado: (2022)

PEDF inhibits non-small cell lung cancer proliferation by suppressing autophagy through downregulation of AMPK-ULK1 signaling
por: Miao, Haoran, et al.
Publicado: (2022)

Mesenchymal stromal cells ameliorate diabetes‐induced muscle atrophy through exosomes by enhancing AMPK/ULK1‐mediated autophagy
por: Song, Jia, et al.
Publicado: (2023)

AMPK/mTOR/ULK1 Axis-Mediated Pathway Participates in Apoptosis and Autophagy Induction by Oridonin in Colon Cancer DLD-1 Cells
por: Bu, Heqi, et al.
Publicado: (2020)

Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy
por: Lu, Qing-Bo, et al.
Publicado: (2022)

TFG: a novel regulator of ULK1-dependent autophagy
por: Cecconi, Francesco, et al.
Publicado: (2021)

ULK1 Signaling in the Liver: Autophagy Dependent and Independent Actions
por: Rajak, Sangam, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_id40ui05emvrnsrd5juhd46b8e