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Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach
INTRODUCTION: Finasteride (FIN) is known as type II 5α-reductase inhibitor, which has been approved for the treatment and prevention of androgenetic alopecia. Administration of FIN by oral route has led to undesirable systemic side effects that include mood disturbance, gynecomastia, decreased libid...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070339/ https://www.ncbi.nlm.nih.gov/pubmed/30104862 http://dx.doi.org/10.2147/DDDT.S171888 |
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author | Ahmed, Osama AA Rizq, Waleed Y |
author_facet | Ahmed, Osama AA Rizq, Waleed Y |
author_sort | Ahmed, Osama AA |
collection | PubMed |
description | INTRODUCTION: Finasteride (FIN) is known as type II 5α-reductase inhibitor, which has been approved for the treatment and prevention of androgenetic alopecia. Administration of FIN by oral route has led to undesirable systemic side effects that include mood disturbance, gynecomastia, decreased libido, erectile dysfunction, and ejaculation disorder. The aim was to improve FIN delivery through skin layers and hair follicles that could possibly reduce its major side effects resulting from long-term oral administration for the treatment and prevention of male pattern baldness. MATERIALS AND METHODS: FIN was formulated as nano-transferosomal (NTF) gel formulations (F1–3). The prepared formulations were characterized for encapsulation efficiency, particle size, ex vivo skin permeation, and kinetic modeling. In addition, visualization of NTF skin penetration using a fluorescence laser microscope was carried out for the selected formula (F2). RESULTS AND DISCUSSION: The results showed that FIN encapsulation efficiency percentage was 69.72 ± 8.36, 89.43 ± 6.82, and 93.1 ± 1.93 for F1, F2, and F3, respectively. FIN-NTF average vesicle sizes were 299.6 ± 45.6, 171 ± 25.6, and 197.4 ± 29.1 nm for F1, F2, and F3, respectively. FIN-NTF formulations (F1–3) showed enhancement and improvement in the amount of FIN permeated compared with raw FIN gel formula. The NTF formula revealed uniform fluorescence (rhodamine) intensity across rat skin, which indicated improved delivery through skin layers compared with control gel formula. CONCLUSION: These results indicated that NTF gel formula showed the ability to boost FIN delivery across skin layers and could be applied as an alternative for oral therapy. |
format | Online Article Text |
id | pubmed-6070339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60703392018-08-13 Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach Ahmed, Osama AA Rizq, Waleed Y Drug Des Devel Ther Original Research INTRODUCTION: Finasteride (FIN) is known as type II 5α-reductase inhibitor, which has been approved for the treatment and prevention of androgenetic alopecia. Administration of FIN by oral route has led to undesirable systemic side effects that include mood disturbance, gynecomastia, decreased libido, erectile dysfunction, and ejaculation disorder. The aim was to improve FIN delivery through skin layers and hair follicles that could possibly reduce its major side effects resulting from long-term oral administration for the treatment and prevention of male pattern baldness. MATERIALS AND METHODS: FIN was formulated as nano-transferosomal (NTF) gel formulations (F1–3). The prepared formulations were characterized for encapsulation efficiency, particle size, ex vivo skin permeation, and kinetic modeling. In addition, visualization of NTF skin penetration using a fluorescence laser microscope was carried out for the selected formula (F2). RESULTS AND DISCUSSION: The results showed that FIN encapsulation efficiency percentage was 69.72 ± 8.36, 89.43 ± 6.82, and 93.1 ± 1.93 for F1, F2, and F3, respectively. FIN-NTF average vesicle sizes were 299.6 ± 45.6, 171 ± 25.6, and 197.4 ± 29.1 nm for F1, F2, and F3, respectively. FIN-NTF formulations (F1–3) showed enhancement and improvement in the amount of FIN permeated compared with raw FIN gel formula. The NTF formula revealed uniform fluorescence (rhodamine) intensity across rat skin, which indicated improved delivery through skin layers compared with control gel formula. CONCLUSION: These results indicated that NTF gel formula showed the ability to boost FIN delivery across skin layers and could be applied as an alternative for oral therapy. Dove Medical Press 2018-07-23 /pmc/articles/PMC6070339/ /pubmed/30104862 http://dx.doi.org/10.2147/DDDT.S171888 Text en © 2018 Ahmed and Rizq. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ahmed, Osama AA Rizq, Waleed Y Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach |
title | Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach |
title_full | Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach |
title_fullStr | Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach |
title_full_unstemmed | Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach |
title_short | Finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach |
title_sort | finasteride nano-transferosomal gel formula for management of androgenetic alopecia: ex vivo investigational approach |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070339/ https://www.ncbi.nlm.nih.gov/pubmed/30104862 http://dx.doi.org/10.2147/DDDT.S171888 |
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