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Linked dimensions of psychopathology and connectivity in functional brain networks

Neurobiological abnormalities associated with psychiatric disorders do not map well to existing diagnostic categories. High co-morbidity suggests dimensional circuit-level abnormalities that cross diagnoses. Here we seek to identify brain-based dimensions of psychopathology using sparse canonical co...

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Autores principales: Xia, Cedric Huchuan, Ma, Zongming, Ciric, Rastko, Gu, Shi, Betzel, Richard F., Kaczkurkin, Antonia N., Calkins, Monica E., Cook, Philip A., García de la Garza, Angel, Vandekar, Simon N., Cui, Zaixu, Moore, Tyler M., Roalf, David R., Ruparel, Kosha, Wolf, Daniel H., Davatzikos, Christos, Gur, Ruben C., Gur, Raquel E., Shinohara, Russell T., Bassett, Danielle S., Satterthwaite, Theodore D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070480/
https://www.ncbi.nlm.nih.gov/pubmed/30068943
http://dx.doi.org/10.1038/s41467-018-05317-y
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author Xia, Cedric Huchuan
Ma, Zongming
Ciric, Rastko
Gu, Shi
Betzel, Richard F.
Kaczkurkin, Antonia N.
Calkins, Monica E.
Cook, Philip A.
García de la Garza, Angel
Vandekar, Simon N.
Cui, Zaixu
Moore, Tyler M.
Roalf, David R.
Ruparel, Kosha
Wolf, Daniel H.
Davatzikos, Christos
Gur, Ruben C.
Gur, Raquel E.
Shinohara, Russell T.
Bassett, Danielle S.
Satterthwaite, Theodore D.
author_facet Xia, Cedric Huchuan
Ma, Zongming
Ciric, Rastko
Gu, Shi
Betzel, Richard F.
Kaczkurkin, Antonia N.
Calkins, Monica E.
Cook, Philip A.
García de la Garza, Angel
Vandekar, Simon N.
Cui, Zaixu
Moore, Tyler M.
Roalf, David R.
Ruparel, Kosha
Wolf, Daniel H.
Davatzikos, Christos
Gur, Ruben C.
Gur, Raquel E.
Shinohara, Russell T.
Bassett, Danielle S.
Satterthwaite, Theodore D.
author_sort Xia, Cedric Huchuan
collection PubMed
description Neurobiological abnormalities associated with psychiatric disorders do not map well to existing diagnostic categories. High co-morbidity suggests dimensional circuit-level abnormalities that cross diagnoses. Here we seek to identify brain-based dimensions of psychopathology using sparse canonical correlation analysis in a sample of 663 youths. This analysis reveals correlated patterns of functional connectivity and psychiatric symptoms. We find that four dimensions of psychopathology – mood, psychosis, fear, and externalizing behavior – are associated (r = 0.68–0.71) with distinct patterns of connectivity. Loss of network segregation between the default mode network and executive networks emerges as a common feature across all dimensions. Connectivity linked to mood and psychosis becomes more prominent with development, and sex differences are present for connectivity related to mood and fear. Critically, findings largely replicate in an independent dataset (n = 336). These results delineate connectivity-guided dimensions of psychopathology that cross clinical diagnostic categories, which could serve as a foundation for developing network-based biomarkers in psychiatry.
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spelling pubmed-60704802018-08-06 Linked dimensions of psychopathology and connectivity in functional brain networks Xia, Cedric Huchuan Ma, Zongming Ciric, Rastko Gu, Shi Betzel, Richard F. Kaczkurkin, Antonia N. Calkins, Monica E. Cook, Philip A. García de la Garza, Angel Vandekar, Simon N. Cui, Zaixu Moore, Tyler M. Roalf, David R. Ruparel, Kosha Wolf, Daniel H. Davatzikos, Christos Gur, Ruben C. Gur, Raquel E. Shinohara, Russell T. Bassett, Danielle S. Satterthwaite, Theodore D. Nat Commun Article Neurobiological abnormalities associated with psychiatric disorders do not map well to existing diagnostic categories. High co-morbidity suggests dimensional circuit-level abnormalities that cross diagnoses. Here we seek to identify brain-based dimensions of psychopathology using sparse canonical correlation analysis in a sample of 663 youths. This analysis reveals correlated patterns of functional connectivity and psychiatric symptoms. We find that four dimensions of psychopathology – mood, psychosis, fear, and externalizing behavior – are associated (r = 0.68–0.71) with distinct patterns of connectivity. Loss of network segregation between the default mode network and executive networks emerges as a common feature across all dimensions. Connectivity linked to mood and psychosis becomes more prominent with development, and sex differences are present for connectivity related to mood and fear. Critically, findings largely replicate in an independent dataset (n = 336). These results delineate connectivity-guided dimensions of psychopathology that cross clinical diagnostic categories, which could serve as a foundation for developing network-based biomarkers in psychiatry. Nature Publishing Group UK 2018-08-01 /pmc/articles/PMC6070480/ /pubmed/30068943 http://dx.doi.org/10.1038/s41467-018-05317-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Xia, Cedric Huchuan
Ma, Zongming
Ciric, Rastko
Gu, Shi
Betzel, Richard F.
Kaczkurkin, Antonia N.
Calkins, Monica E.
Cook, Philip A.
García de la Garza, Angel
Vandekar, Simon N.
Cui, Zaixu
Moore, Tyler M.
Roalf, David R.
Ruparel, Kosha
Wolf, Daniel H.
Davatzikos, Christos
Gur, Ruben C.
Gur, Raquel E.
Shinohara, Russell T.
Bassett, Danielle S.
Satterthwaite, Theodore D.
Linked dimensions of psychopathology and connectivity in functional brain networks
title Linked dimensions of psychopathology and connectivity in functional brain networks
title_full Linked dimensions of psychopathology and connectivity in functional brain networks
title_fullStr Linked dimensions of psychopathology and connectivity in functional brain networks
title_full_unstemmed Linked dimensions of psychopathology and connectivity in functional brain networks
title_short Linked dimensions of psychopathology and connectivity in functional brain networks
title_sort linked dimensions of psychopathology and connectivity in functional brain networks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070480/
https://www.ncbi.nlm.nih.gov/pubmed/30068943
http://dx.doi.org/10.1038/s41467-018-05317-y
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