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A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070519/ https://www.ncbi.nlm.nih.gov/pubmed/30069010 http://dx.doi.org/10.1038/s41598-018-29011-7 |
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| author | Kou, Ikuyo Watanabe, Kota Takahashi, Yohei Momozawa, Yukihide Khanshour, Anas Grauers, Anna Zhou, Hang Liu, Gang Fan, Yan-Hui Takeda, Kazuki Ogura, Yoji Zhou, Taifeng Iwasaki, Yusuke Kubo, Michiaki Wu, Zhihong Matsumoto, Morio Einarsdottir, Elisabet Kere, Juha Huang, Dongsheng Qiu, Guixing Qiu, Yong Wise, Carol A. Song, You-Qiang Wu, Nan Su, Peiqiang Gerdhem, Paul Ikegawa, Shiro |
| author_facet | Kou, Ikuyo Watanabe, Kota Takahashi, Yohei Momozawa, Yukihide Khanshour, Anas Grauers, Anna Zhou, Hang Liu, Gang Fan, Yan-Hui Takeda, Kazuki Ogura, Yoji Zhou, Taifeng Iwasaki, Yusuke Kubo, Michiaki Wu, Zhihong Matsumoto, Morio Einarsdottir, Elisabet Kere, Juha Huang, Dongsheng Qiu, Guixing Qiu, Yong Wise, Carol A. Song, You-Qiang Wu, Nan Su, Peiqiang Gerdhem, Paul Ikegawa, Shiro |
| author_sort | Kou, Ikuyo |
| collection | PubMed |
| description | Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. The locus is represented by rs6570507 located within GPR126. To ensure the association of rs6570507 with AIS, we conducted a meta-analysis using eight cohorts from East Asia, Northern Europe and USA. The analysis included a total of 6,873 cases and 38,916 controls and yielded significant association (combined P = 2.95 × 10(−20); odds ratio = 1.22), providing convincing evidence of the worldwide association between rs6570507 and AIS susceptibility. In silico analyses strongly suggested that GPR126 is a susceptibility gene at this locus. |
| format | Online Article Text |
| id | pubmed-6070519 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-60705192018-08-06 A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis Kou, Ikuyo Watanabe, Kota Takahashi, Yohei Momozawa, Yukihide Khanshour, Anas Grauers, Anna Zhou, Hang Liu, Gang Fan, Yan-Hui Takeda, Kazuki Ogura, Yoji Zhou, Taifeng Iwasaki, Yusuke Kubo, Michiaki Wu, Zhihong Matsumoto, Morio Einarsdottir, Elisabet Kere, Juha Huang, Dongsheng Qiu, Guixing Qiu, Yong Wise, Carol A. Song, You-Qiang Wu, Nan Su, Peiqiang Gerdhem, Paul Ikegawa, Shiro Sci Rep Article Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. The locus is represented by rs6570507 located within GPR126. To ensure the association of rs6570507 with AIS, we conducted a meta-analysis using eight cohorts from East Asia, Northern Europe and USA. The analysis included a total of 6,873 cases and 38,916 controls and yielded significant association (combined P = 2.95 × 10(−20); odds ratio = 1.22), providing convincing evidence of the worldwide association between rs6570507 and AIS susceptibility. In silico analyses strongly suggested that GPR126 is a susceptibility gene at this locus. Nature Publishing Group UK 2018-08-01 /pmc/articles/PMC6070519/ /pubmed/30069010 http://dx.doi.org/10.1038/s41598-018-29011-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Kou, Ikuyo Watanabe, Kota Takahashi, Yohei Momozawa, Yukihide Khanshour, Anas Grauers, Anna Zhou, Hang Liu, Gang Fan, Yan-Hui Takeda, Kazuki Ogura, Yoji Zhou, Taifeng Iwasaki, Yusuke Kubo, Michiaki Wu, Zhihong Matsumoto, Morio Einarsdottir, Elisabet Kere, Juha Huang, Dongsheng Qiu, Guixing Qiu, Yong Wise, Carol A. Song, You-Qiang Wu, Nan Su, Peiqiang Gerdhem, Paul Ikegawa, Shiro A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis |
| title | A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis |
| title_full | A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis |
| title_fullStr | A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis |
| title_full_unstemmed | A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis |
| title_short | A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis |
| title_sort | multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070519/ https://www.ncbi.nlm.nih.gov/pubmed/30069010 http://dx.doi.org/10.1038/s41598-018-29011-7 |
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