Male increase in brain gene expression variability is linked to genetic risk for schizophrenia

Schizophrenia shows substantial sex differences in age of onset, course, and treatment response, but the biological basis of these effects is incompletely understood. Here we show that during human development, males show a regionally specific decrease in brain expression similarity compared to fema...

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Autores principales: Chen, Junfang, Cao, Han, Meyer-Lindenberg, Andreas, Schwarz, Emanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070530/
https://www.ncbi.nlm.nih.gov/pubmed/30068996
http://dx.doi.org/10.1038/s41398-018-0200-0
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author Chen, Junfang
Cao, Han
Meyer-Lindenberg, Andreas
Schwarz, Emanuel
author_facet Chen, Junfang
Cao, Han
Meyer-Lindenberg, Andreas
Schwarz, Emanuel
author_sort Chen, Junfang
collection PubMed
description Schizophrenia shows substantial sex differences in age of onset, course, and treatment response, but the biological basis of these effects is incompletely understood. Here we show that during human development, males show a regionally specific decrease in brain expression similarity compared to females. The genes modulating this effect were significantly co-expressed with schizophrenia risk genes during prefrontal cortex brain development in the fetal period as well as during early adolescence. This suggests a genetic contribution to a mechanism through which developmental abnormalities manifest with psychosis during adolescence. It further supports sex differences in brain expression variability as a factor underlying the well-established sex differences in schizophrenia.
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spelling pubmed-60705302018-08-02 Male increase in brain gene expression variability is linked to genetic risk for schizophrenia Chen, Junfang Cao, Han Meyer-Lindenberg, Andreas Schwarz, Emanuel Transl Psychiatry Article Schizophrenia shows substantial sex differences in age of onset, course, and treatment response, but the biological basis of these effects is incompletely understood. Here we show that during human development, males show a regionally specific decrease in brain expression similarity compared to females. The genes modulating this effect were significantly co-expressed with schizophrenia risk genes during prefrontal cortex brain development in the fetal period as well as during early adolescence. This suggests a genetic contribution to a mechanism through which developmental abnormalities manifest with psychosis during adolescence. It further supports sex differences in brain expression variability as a factor underlying the well-established sex differences in schizophrenia. Nature Publishing Group UK 2018-08-01 /pmc/articles/PMC6070530/ /pubmed/30068996 http://dx.doi.org/10.1038/s41398-018-0200-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Junfang
Cao, Han
Meyer-Lindenberg, Andreas
Schwarz, Emanuel
Male increase in brain gene expression variability is linked to genetic risk for schizophrenia
title Male increase in brain gene expression variability is linked to genetic risk for schizophrenia
title_full Male increase in brain gene expression variability is linked to genetic risk for schizophrenia
title_fullStr Male increase in brain gene expression variability is linked to genetic risk for schizophrenia
title_full_unstemmed Male increase in brain gene expression variability is linked to genetic risk for schizophrenia
title_short Male increase in brain gene expression variability is linked to genetic risk for schizophrenia
title_sort male increase in brain gene expression variability is linked to genetic risk for schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070530/
https://www.ncbi.nlm.nih.gov/pubmed/30068996
http://dx.doi.org/10.1038/s41398-018-0200-0
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