Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells

Cancer stem cells (CSCs) are a small population of resistant cells inhabiting the tumors. Although comprising only nearly 3% of the tumor mass, these cells were demonstrated to orchestrate tumorigenesis and differentiation, underlie tumors’ heterogeneity and mediate therapy resistance and tumor rela...

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Detalles Bibliográficos
Autores principales: Rodrigues, Carlos F. D., Serrano, Eurico, Patrício, Maria I., Val, Mariana M., Albuquerque, Patrícia, Fonseca, João, Gomes, Célia M. F., Abrunhosa, Antero J., Paiva, Artur, Carvalho, Lina, Botelho, M. Filomena, Almeida, Luís, Carreira, Isabel M., Alpoim, Maria Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070555/
https://www.ncbi.nlm.nih.gov/pubmed/30069023
http://dx.doi.org/10.1038/s41598-018-29947-w

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