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BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines

Beta-site amyloid-precursor-protein cleaving enzyme 1 (BACE1) is the rate limiting protease in the production of the amyloid-beta peptide (Aβ), which is considered to be the causative agent in the pathogenesis of Alzheimer’s Disease (AD). Therefore, the therapeutic potential of pharmacological BACE1...

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Detalles Bibliográficos
Autores principales:	Blume, Tanja, Filser, Severin, Jaworska, Anna, Blain, Jean-Francois, Koenig, Gerhard, Moschke, Katrin, Lichtenthaler, Stefan F., Herms, Jochen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070607/ https://www.ncbi.nlm.nih.gov/pubmed/30093858 http://dx.doi.org/10.3389/fnagi.2018.00229

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