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Conformational transition pathway of R308K mutant glucokinase in the presence of the glucokinase activator YNKGKA4
Glucokinase (GK) plays a vital role in the control of blood glucose levels and its altered activity can lead to the development of forms of diabetes. We have previously identified a mutant GK (R308K) in patients with type 2 diabetes with reduced enzyme activity. In the present study, the activation...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070654/ https://www.ncbi.nlm.nih.gov/pubmed/30087826 http://dx.doi.org/10.1002/2211-5463.12255 |