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Loss of runx1 function results in B cell immunodeficiency but not T cell in adult zebrafish

Transcription factor RUNX1 holds an integral role in multiple-lineage haematopoiesis and is implicated as a cofactor in V(D)J rearrangements during lymphocyte development. Runx1 deficiencies resulted in immaturity and reduction of lymphocytes in mice. In this study, we found that runx1(W84X/W84X) mu...

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Detalles Bibliográficos
Autores principales:	Chi, Yali, Huang, Zhibin, Chen, Qi, Xiong, Xiaojie, Chen, Kemin, Xu, Jin, Zhang, Yiyue, Zhang, Wenqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070721/ https://www.ncbi.nlm.nih.gov/pubmed/30045885 http://dx.doi.org/10.1098/rsob.180043

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