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First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines

Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target many pat...

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Detalles Bibliográficos
Autores principales: Borriello, Francesco, van Haren, Simon D., Levy, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070736/
https://www.ncbi.nlm.nih.gov/pubmed/30068557
http://dx.doi.org/10.1128/mSphere.00214-18
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author Borriello, Francesco
van Haren, Simon D.
Levy, Ofer
author_facet Borriello, Francesco
van Haren, Simon D.
Levy, Ofer
author_sort Borriello, Francesco
collection PubMed
description Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target many pathogens due to intrinsic features of the microorganism, such as genetic/antigenic variability between strains, and our limited understanding of the variables that regulate vaccine responsiveness, including age- and sex-specific differences. Moreover, the traditional approach to vaccine development is often empirical, relying on inactivation of microorganisms or purification of their components, which are usually less immunogenic than the whole microorganism from which they derive. This approach has yielded multiple important vaccines but has failed to consistently generate vaccines that are sufficiently immunogenic in populations with limited immune responsiveness such as newborns and elderly individuals. In an effort to trigger impactful collaborations, a community of scientists gathered in Boston in the United States for the first biennial International Precision Vaccines Conference, sponsored by the Boston Children’s Hospital Precision Vaccines Program, to discuss innovation in vaccinology. Recent advancements in the field of systems biology that can identify vaccine immunogenicity biomarkers for target populations, in human in vitro models, and in novel adjuvant and formulation strategies offer unprecedented opportunities to dissect the human immune response to vaccines and inform dramatic improvements in vaccine efficacy. These approaches are poised to have a major scientific and translational impact in vaccinology.
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spelling pubmed-60707362018-08-31 First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines Borriello, Francesco van Haren, Simon D. Levy, Ofer mSphere Meeting Highlights Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target many pathogens due to intrinsic features of the microorganism, such as genetic/antigenic variability between strains, and our limited understanding of the variables that regulate vaccine responsiveness, including age- and sex-specific differences. Moreover, the traditional approach to vaccine development is often empirical, relying on inactivation of microorganisms or purification of their components, which are usually less immunogenic than the whole microorganism from which they derive. This approach has yielded multiple important vaccines but has failed to consistently generate vaccines that are sufficiently immunogenic in populations with limited immune responsiveness such as newborns and elderly individuals. In an effort to trigger impactful collaborations, a community of scientists gathered in Boston in the United States for the first biennial International Precision Vaccines Conference, sponsored by the Boston Children’s Hospital Precision Vaccines Program, to discuss innovation in vaccinology. Recent advancements in the field of systems biology that can identify vaccine immunogenicity biomarkers for target populations, in human in vitro models, and in novel adjuvant and formulation strategies offer unprecedented opportunities to dissect the human immune response to vaccines and inform dramatic improvements in vaccine efficacy. These approaches are poised to have a major scientific and translational impact in vaccinology. American Society for Microbiology 2018-08-01 /pmc/articles/PMC6070736/ /pubmed/30068557 http://dx.doi.org/10.1128/mSphere.00214-18 Text en Copyright © 2018 Borriello et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Meeting Highlights
Borriello, Francesco
van Haren, Simon D.
Levy, Ofer
First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title_full First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title_fullStr First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title_full_unstemmed First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title_short First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title_sort first international precision vaccines conference: multidisciplinary approaches to next-generation vaccines
topic Meeting Highlights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070736/
https://www.ncbi.nlm.nih.gov/pubmed/30068557
http://dx.doi.org/10.1128/mSphere.00214-18
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