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First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target many pat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070736/ https://www.ncbi.nlm.nih.gov/pubmed/30068557 http://dx.doi.org/10.1128/mSphere.00214-18 |
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author | Borriello, Francesco van Haren, Simon D. Levy, Ofer |
author_facet | Borriello, Francesco van Haren, Simon D. Levy, Ofer |
author_sort | Borriello, Francesco |
collection | PubMed |
description | Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target many pathogens due to intrinsic features of the microorganism, such as genetic/antigenic variability between strains, and our limited understanding of the variables that regulate vaccine responsiveness, including age- and sex-specific differences. Moreover, the traditional approach to vaccine development is often empirical, relying on inactivation of microorganisms or purification of their components, which are usually less immunogenic than the whole microorganism from which they derive. This approach has yielded multiple important vaccines but has failed to consistently generate vaccines that are sufficiently immunogenic in populations with limited immune responsiveness such as newborns and elderly individuals. In an effort to trigger impactful collaborations, a community of scientists gathered in Boston in the United States for the first biennial International Precision Vaccines Conference, sponsored by the Boston Children’s Hospital Precision Vaccines Program, to discuss innovation in vaccinology. Recent advancements in the field of systems biology that can identify vaccine immunogenicity biomarkers for target populations, in human in vitro models, and in novel adjuvant and formulation strategies offer unprecedented opportunities to dissect the human immune response to vaccines and inform dramatic improvements in vaccine efficacy. These approaches are poised to have a major scientific and translational impact in vaccinology. |
format | Online Article Text |
id | pubmed-6070736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-60707362018-08-31 First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines Borriello, Francesco van Haren, Simon D. Levy, Ofer mSphere Meeting Highlights Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target many pathogens due to intrinsic features of the microorganism, such as genetic/antigenic variability between strains, and our limited understanding of the variables that regulate vaccine responsiveness, including age- and sex-specific differences. Moreover, the traditional approach to vaccine development is often empirical, relying on inactivation of microorganisms or purification of their components, which are usually less immunogenic than the whole microorganism from which they derive. This approach has yielded multiple important vaccines but has failed to consistently generate vaccines that are sufficiently immunogenic in populations with limited immune responsiveness such as newborns and elderly individuals. In an effort to trigger impactful collaborations, a community of scientists gathered in Boston in the United States for the first biennial International Precision Vaccines Conference, sponsored by the Boston Children’s Hospital Precision Vaccines Program, to discuss innovation in vaccinology. Recent advancements in the field of systems biology that can identify vaccine immunogenicity biomarkers for target populations, in human in vitro models, and in novel adjuvant and formulation strategies offer unprecedented opportunities to dissect the human immune response to vaccines and inform dramatic improvements in vaccine efficacy. These approaches are poised to have a major scientific and translational impact in vaccinology. American Society for Microbiology 2018-08-01 /pmc/articles/PMC6070736/ /pubmed/30068557 http://dx.doi.org/10.1128/mSphere.00214-18 Text en Copyright © 2018 Borriello et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Meeting Highlights Borriello, Francesco van Haren, Simon D. Levy, Ofer First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
title | First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
title_full | First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
title_fullStr | First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
title_full_unstemmed | First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
title_short | First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines |
title_sort | first international precision vaccines conference: multidisciplinary approaches to next-generation vaccines |
topic | Meeting Highlights |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070736/ https://www.ncbi.nlm.nih.gov/pubmed/30068557 http://dx.doi.org/10.1128/mSphere.00214-18 |
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