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Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies

Parkinson's disease (PD) is a neurodegenerative disorder accompanied by a series of pathological mechanisms which contribute to a variety of motor and non-motor symptoms. Recently, there has been an increasing interest in structural diffusion tensor imaging (DTI) in PD which has shed light on o...

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Autores principales: Haghshomar, Maryam, Dolatshahi, Mahsa, Ghazi Sherbaf, Farzaneh, Sanjari Moghaddam, Hossein, Shirin Shandiz, Mehdi, Aarabi, Mohammad Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070770/
https://www.ncbi.nlm.nih.gov/pubmed/30093877
http://dx.doi.org/10.3389/fneur.2018.00598
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author Haghshomar, Maryam
Dolatshahi, Mahsa
Ghazi Sherbaf, Farzaneh
Sanjari Moghaddam, Hossein
Shirin Shandiz, Mehdi
Aarabi, Mohammad Hadi
author_facet Haghshomar, Maryam
Dolatshahi, Mahsa
Ghazi Sherbaf, Farzaneh
Sanjari Moghaddam, Hossein
Shirin Shandiz, Mehdi
Aarabi, Mohammad Hadi
author_sort Haghshomar, Maryam
collection PubMed
description Parkinson's disease (PD) is a neurodegenerative disorder accompanied by a series of pathological mechanisms which contribute to a variety of motor and non-motor symptoms. Recently, there has been an increasing interest in structural diffusion tensor imaging (DTI) in PD which has shed light on our understanding of structural abnormalities underlying PD symptoms or its associations with pathological mechanisms. One of the white matter tracts shown to be disrupted in PD with a possible contribution to some PD symptoms is the inferior longitudinal fasciculus (ILF). On the whole, lower ILF integrity contributes to thought disorders, impaired visual emotions, cognitive impairments such as semantic fluency deficits, and mood disorders. This review outlines the microstructural changes in ILF associated with systemic inflammation and various PD symptoms like cognitive decline, facial emotion recognition deficit, depression, color discrimination deficit, olfactory dysfunction, and tremor genesis. However, few studies have investigated DTI correlates of each symptom and larger studies with standardized imaging protocols are required to extend these preliminary findings and lead to more promising results.
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spelling pubmed-60707702018-08-09 Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies Haghshomar, Maryam Dolatshahi, Mahsa Ghazi Sherbaf, Farzaneh Sanjari Moghaddam, Hossein Shirin Shandiz, Mehdi Aarabi, Mohammad Hadi Front Neurol Neurology Parkinson's disease (PD) is a neurodegenerative disorder accompanied by a series of pathological mechanisms which contribute to a variety of motor and non-motor symptoms. Recently, there has been an increasing interest in structural diffusion tensor imaging (DTI) in PD which has shed light on our understanding of structural abnormalities underlying PD symptoms or its associations with pathological mechanisms. One of the white matter tracts shown to be disrupted in PD with a possible contribution to some PD symptoms is the inferior longitudinal fasciculus (ILF). On the whole, lower ILF integrity contributes to thought disorders, impaired visual emotions, cognitive impairments such as semantic fluency deficits, and mood disorders. This review outlines the microstructural changes in ILF associated with systemic inflammation and various PD symptoms like cognitive decline, facial emotion recognition deficit, depression, color discrimination deficit, olfactory dysfunction, and tremor genesis. However, few studies have investigated DTI correlates of each symptom and larger studies with standardized imaging protocols are required to extend these preliminary findings and lead to more promising results. Frontiers Media S.A. 2018-07-26 /pmc/articles/PMC6070770/ /pubmed/30093877 http://dx.doi.org/10.3389/fneur.2018.00598 Text en Copyright © 2018 Haghshomar, Dolatshahi, Ghazi Sherbaf, Sanjari Moghaddam, Shirin Shandiz and Aarabi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Haghshomar, Maryam
Dolatshahi, Mahsa
Ghazi Sherbaf, Farzaneh
Sanjari Moghaddam, Hossein
Shirin Shandiz, Mehdi
Aarabi, Mohammad Hadi
Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies
title Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies
title_full Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies
title_fullStr Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies
title_full_unstemmed Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies
title_short Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies
title_sort disruption of inferior longitudinal fasciculus microstructure in parkinson's disease: a systematic review of diffusion tensor imaging studies
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070770/
https://www.ncbi.nlm.nih.gov/pubmed/30093877
http://dx.doi.org/10.3389/fneur.2018.00598
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