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Weighted Gene Co-Expression Network Analysis Reveals Dysregulation of Mitochondrial Oxidative Phosphorylation in Eating Disorders

The underlying mechanisms of eating disorders (EDs) are very complicated and still poorly understood. The pathogenesis of EDs may involve the interplay of multiple genes. To investigate the dysregulated gene pathways in EDs we analyzed gene expression profiling in dorsolateral prefrontal cortex (DLP...

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Autores principales: Yang, Liulin, Li, Yun, Turki, Turki, Tan, Huizi, Wei, Zhi, Chang, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070803/
https://www.ncbi.nlm.nih.gov/pubmed/29958387
http://dx.doi.org/10.3390/genes9070325
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author Yang, Liulin
Li, Yun
Turki, Turki
Tan, Huizi
Wei, Zhi
Chang, Xiao
author_facet Yang, Liulin
Li, Yun
Turki, Turki
Tan, Huizi
Wei, Zhi
Chang, Xiao
author_sort Yang, Liulin
collection PubMed
description The underlying mechanisms of eating disorders (EDs) are very complicated and still poorly understood. The pathogenesis of EDs may involve the interplay of multiple genes. To investigate the dysregulated gene pathways in EDs we analyzed gene expression profiling in dorsolateral prefrontal cortex (DLPFC) tissues from 15 EDs cases, including 3 with anorexia nervosa (AN), 7 with bulimia nervosa (BN), 2 AN-BN cases, 3 cases of EDs not otherwise specified, and 102 controls. We further used a weighted gene co-expression network analysis to construct a gene co-expression network and to detect functional modules of highly correlated genes. The functional enrichment analysis of genes in co-expression modules indicated that an altered mitochondrial oxidative phosphorylation process may be involved in the pathogenesis of EDs.
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spelling pubmed-60708032018-08-09 Weighted Gene Co-Expression Network Analysis Reveals Dysregulation of Mitochondrial Oxidative Phosphorylation in Eating Disorders Yang, Liulin Li, Yun Turki, Turki Tan, Huizi Wei, Zhi Chang, Xiao Genes (Basel) Article The underlying mechanisms of eating disorders (EDs) are very complicated and still poorly understood. The pathogenesis of EDs may involve the interplay of multiple genes. To investigate the dysregulated gene pathways in EDs we analyzed gene expression profiling in dorsolateral prefrontal cortex (DLPFC) tissues from 15 EDs cases, including 3 with anorexia nervosa (AN), 7 with bulimia nervosa (BN), 2 AN-BN cases, 3 cases of EDs not otherwise specified, and 102 controls. We further used a weighted gene co-expression network analysis to construct a gene co-expression network and to detect functional modules of highly correlated genes. The functional enrichment analysis of genes in co-expression modules indicated that an altered mitochondrial oxidative phosphorylation process may be involved in the pathogenesis of EDs. MDPI 2018-06-28 /pmc/articles/PMC6070803/ /pubmed/29958387 http://dx.doi.org/10.3390/genes9070325 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Liulin
Li, Yun
Turki, Turki
Tan, Huizi
Wei, Zhi
Chang, Xiao
Weighted Gene Co-Expression Network Analysis Reveals Dysregulation of Mitochondrial Oxidative Phosphorylation in Eating Disorders
title Weighted Gene Co-Expression Network Analysis Reveals Dysregulation of Mitochondrial Oxidative Phosphorylation in Eating Disorders
title_full Weighted Gene Co-Expression Network Analysis Reveals Dysregulation of Mitochondrial Oxidative Phosphorylation in Eating Disorders
title_fullStr Weighted Gene Co-Expression Network Analysis Reveals Dysregulation of Mitochondrial Oxidative Phosphorylation in Eating Disorders
title_full_unstemmed Weighted Gene Co-Expression Network Analysis Reveals Dysregulation of Mitochondrial Oxidative Phosphorylation in Eating Disorders
title_short Weighted Gene Co-Expression Network Analysis Reveals Dysregulation of Mitochondrial Oxidative Phosphorylation in Eating Disorders
title_sort weighted gene co-expression network analysis reveals dysregulation of mitochondrial oxidative phosphorylation in eating disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070803/
https://www.ncbi.nlm.nih.gov/pubmed/29958387
http://dx.doi.org/10.3390/genes9070325
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