Mitochondrial HTRA2 Plays a Positive, Protective Role in Dictyostelium discoideum but Is Cytotoxic When Overexpressed

HTRA2 is a mitochondrial protein, mutations in which are associated with autosomal dominant late-onset Parkinson’s disease (PD). The mechanisms by which HTRA2 mutations result in PD are poorly understood. HTRA2 is proposed to play a proteolytic role in protein quality control and homeostasis in the...

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Detalles Bibliográficos
Autores principales: Chen, Suwei, Sanislav, Oana, Annesley, Sarah J., Fisher, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070809/
https://www.ncbi.nlm.nih.gov/pubmed/30013019
http://dx.doi.org/10.3390/genes9070355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070809/
https://www.ncbi.nlm.nih.gov/pubmed/30013019
http://dx.doi.org/10.3390/genes9070355

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