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Characterisation of tumour microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact (an OCTIPS Consortium study).

BACKGROUND: High-grade serous ovarian cancer (HGSOC) intratumoural vasculature evolution remains unknown. The study investigated changes in tumour microvessel density (MVD) in a large cohort of paired primary and recurrent HGSOC tissue samples and its impact on patients’ clinico-pathological outcome...

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Detalles Bibliográficos
Autores principales: Ruscito, Ilary, Cacsire Castillo-Tong, Dan, Vergote, Ignace, Ignat, Iulia, Stanske, Mandy, Vanderstichele, Adriaan, Glajzer, Jacek, Kulbe, Hagen, Trillsch, Fabian, Mustea, Alexander, Kreuzinger, Caroline, Benedetti Panici, Pierluigi, Gourley, Charlie, Gabra, Hani, Nuti, Marianna, Taube, Eliane T., Kessler, Mirjana, Sehouli, Jalid, Darb-Esfahani, Silvia, Braicu, Elena Ioana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070919/
https://www.ncbi.nlm.nih.gov/pubmed/29955134
http://dx.doi.org/10.1038/s41416-018-0157-z
Descripción
Sumario:BACKGROUND: High-grade serous ovarian cancer (HGSOC) intratumoural vasculature evolution remains unknown. The study investigated changes in tumour microvessel density (MVD) in a large cohort of paired primary and recurrent HGSOC tissue samples and its impact on patients’ clinico-pathological outcome. METHODS: A total of 222 primary (pOC) and recurrent (rOC) intra-patient paired HGSOC were assessed for immunohistochemical expression of angiogenesis-associated biomarkers (CD31, to evaluate MVD, and VEGF-A). Expression profiles were compared between pOCs and rOCs and correlated with patients' data. RESULTS: High intratumoural MVD and VEGF-A expression were observed in 75.7% (84/111) and 20.7% (23/111) pOCs, respectively. MVD(high) and VEGF((+)) samples were detected in 51.4% (57/111) and 20.7% (23/111) rOCs, respectively. MVD(high)/VEGF((+)) co-expression was found in 19.8% (22/111) and 8.1% (9/111) of pOCs and rOCs, respectively (p = 0.02). Pairwise analysis showed no significant change in MVD (p = 0.935) and VEGF-A (p = 0.121) levels from pOCs to rOCs. MVD(high) pOCs were associated with higher CD3((+)) (p = 0.029) and CD8((+)) (p = 0.013) intratumoural effector TILs, while VEGF((+)) samples were most frequently encountered among BRCA-mutated tumours (p = 0.019). Multivariate analysis showed VEGF and MVD were not independent prognostic factors for OS. CONCLUSIONS: HGSOC intratumoural vasculature did not undergo significant changes during disease progression. High concentration of CD31((+)) vessels seems to promote recruitment of effector TILs. The study also provides preliminary evidence of the correlation between VEGF-positivity and BRCA status.