TRPM2 in the Brain: Role in Health and Disease

Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and in...

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Autores principales: Sita, Giulia, Hrelia, Patrizia, Graziosi, Agnese, Ravegnini, Gloria, Morroni, Fabiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070997/
https://www.ncbi.nlm.nih.gov/pubmed/30037128
http://dx.doi.org/10.3390/cells7070082
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author Sita, Giulia
Hrelia, Patrizia
Graziosi, Agnese
Ravegnini, Gloria
Morroni, Fabiana
author_facet Sita, Giulia
Hrelia, Patrizia
Graziosi, Agnese
Ravegnini, Gloria
Morroni, Fabiana
author_sort Sita, Giulia
collection PubMed
description Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and inflammation, while its activity depends on the presence of intracellular calcium (Ca(2+)). TRPM2 is involved in several physiological and pathological processes in the brain through the modulation of multiple signaling pathways. The aim of the present review is to provide a brief summary of the current insights of TRPM2 role in health and disease to focalize our attention on future potential neuroprotective strategies.
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spelling pubmed-60709972018-08-09 TRPM2 in the Brain: Role in Health and Disease Sita, Giulia Hrelia, Patrizia Graziosi, Agnese Ravegnini, Gloria Morroni, Fabiana Cells Review Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involved in the response to oxidative stress and inflammation, while its activity depends on the presence of intracellular calcium (Ca(2+)). TRPM2 is involved in several physiological and pathological processes in the brain through the modulation of multiple signaling pathways. The aim of the present review is to provide a brief summary of the current insights of TRPM2 role in health and disease to focalize our attention on future potential neuroprotective strategies. MDPI 2018-07-22 /pmc/articles/PMC6070997/ /pubmed/30037128 http://dx.doi.org/10.3390/cells7070082 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sita, Giulia
Hrelia, Patrizia
Graziosi, Agnese
Ravegnini, Gloria
Morroni, Fabiana
TRPM2 in the Brain: Role in Health and Disease
title TRPM2 in the Brain: Role in Health and Disease
title_full TRPM2 in the Brain: Role in Health and Disease
title_fullStr TRPM2 in the Brain: Role in Health and Disease
title_full_unstemmed TRPM2 in the Brain: Role in Health and Disease
title_short TRPM2 in the Brain: Role in Health and Disease
title_sort trpm2 in the brain: role in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070997/
https://www.ncbi.nlm.nih.gov/pubmed/30037128
http://dx.doi.org/10.3390/cells7070082
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