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Near-infrared laser-mediated drug release and antibacterial activity of gold nanorod–sputtered titania nanotubes

The infection control of implants is one of the hot issues in the field of medicine and dentistry. In this study, we prepared gold nanorod–sputtered titania nanotubes on titanium surface, which is the main component of implant material, and aimed to estimate the remote-controlled tetracycline releas...

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Autores principales: Moon, Kyoung-Suk, Park, Young-Bum, Bae, Ji-Myung, Oh, Seunghan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071157/
https://www.ncbi.nlm.nih.gov/pubmed/30083309
http://dx.doi.org/10.1177/2041731418790315
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author Moon, Kyoung-Suk
Park, Young-Bum
Bae, Ji-Myung
Oh, Seunghan
author_facet Moon, Kyoung-Suk
Park, Young-Bum
Bae, Ji-Myung
Oh, Seunghan
author_sort Moon, Kyoung-Suk
collection PubMed
description The infection control of implants is one of the hot issues in the field of medicine and dentistry. In this study, we prepared gold nanorod–sputtered titania nanotubes on titanium surface, which is the main component of implant material, and aimed to estimate the remote-controlled tetracycline release and resulting antibacterial effects of gold nanorod–sputtered titania nanotubes using near-infrared laser irradiation. Gold nanorods prepared by ion plasma sputtering (aspect ratio = 1:3) showed optical properties like those of chemically synthesized gold nanorods, exhibiting photothermal effects in the near-infrared region, as demonstrated using field-emission scanning electron microscopy, transmission electron microscopy, and diffuse ultraviolet–visible–near-infrared spectrophotometry. In addition, a 2 wt% tetracycline/polycaprolactone mixture was found to be the most suitable experimental group to demonstrate the biological compatibilities and antibacterial activities. The results of antibacterial agar diffusion tests and near-infrared-mediated tetracycline release tests in vivo confirmed that remote-controlled tetracycline elution using near-infrared laser irradiation was highly effective. Therefore, gold nanorod–sputtered titania nanotubes would be expected to enable the continued use of the photothermal therapy of gold nanorods and extend the limited use of titania showing photocatalytic activity only within the ultraviolet-to-near-infrared region.
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spelling pubmed-60711572018-08-06 Near-infrared laser-mediated drug release and antibacterial activity of gold nanorod–sputtered titania nanotubes Moon, Kyoung-Suk Park, Young-Bum Bae, Ji-Myung Oh, Seunghan J Tissue Eng Functional Biomaterials and Extracellular Matrices for Dental Tissue Repair and Regeneration The infection control of implants is one of the hot issues in the field of medicine and dentistry. In this study, we prepared gold nanorod–sputtered titania nanotubes on titanium surface, which is the main component of implant material, and aimed to estimate the remote-controlled tetracycline release and resulting antibacterial effects of gold nanorod–sputtered titania nanotubes using near-infrared laser irradiation. Gold nanorods prepared by ion plasma sputtering (aspect ratio = 1:3) showed optical properties like those of chemically synthesized gold nanorods, exhibiting photothermal effects in the near-infrared region, as demonstrated using field-emission scanning electron microscopy, transmission electron microscopy, and diffuse ultraviolet–visible–near-infrared spectrophotometry. In addition, a 2 wt% tetracycline/polycaprolactone mixture was found to be the most suitable experimental group to demonstrate the biological compatibilities and antibacterial activities. The results of antibacterial agar diffusion tests and near-infrared-mediated tetracycline release tests in vivo confirmed that remote-controlled tetracycline elution using near-infrared laser irradiation was highly effective. Therefore, gold nanorod–sputtered titania nanotubes would be expected to enable the continued use of the photothermal therapy of gold nanorods and extend the limited use of titania showing photocatalytic activity only within the ultraviolet-to-near-infrared region. SAGE Publications 2018-07-26 /pmc/articles/PMC6071157/ /pubmed/30083309 http://dx.doi.org/10.1177/2041731418790315 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Functional Biomaterials and Extracellular Matrices for Dental Tissue Repair and Regeneration
Moon, Kyoung-Suk
Park, Young-Bum
Bae, Ji-Myung
Oh, Seunghan
Near-infrared laser-mediated drug release and antibacterial activity of gold nanorod–sputtered titania nanotubes
title Near-infrared laser-mediated drug release and antibacterial activity of gold nanorod–sputtered titania nanotubes
title_full Near-infrared laser-mediated drug release and antibacterial activity of gold nanorod–sputtered titania nanotubes
title_fullStr Near-infrared laser-mediated drug release and antibacterial activity of gold nanorod–sputtered titania nanotubes
title_full_unstemmed Near-infrared laser-mediated drug release and antibacterial activity of gold nanorod–sputtered titania nanotubes
title_short Near-infrared laser-mediated drug release and antibacterial activity of gold nanorod–sputtered titania nanotubes
title_sort near-infrared laser-mediated drug release and antibacterial activity of gold nanorod–sputtered titania nanotubes
topic Functional Biomaterials and Extracellular Matrices for Dental Tissue Repair and Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071157/
https://www.ncbi.nlm.nih.gov/pubmed/30083309
http://dx.doi.org/10.1177/2041731418790315
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