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Antibacterial surface modification of titanium implants in orthopaedics

The use of biomaterials in orthopaedics for joint replacement, fracture healing and bone regeneration is a rapidly expanding field. Infection of these biomaterials is a major healthcare burden, leading to significant morbidity and mortality. Furthermore, the cost to healthcare systems is increasing...

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Autores principales: Orapiriyakul, Wich, Young, Peter S, Damiati, Laila, Tsimbouri, Penelope M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071164/
https://www.ncbi.nlm.nih.gov/pubmed/30083308
http://dx.doi.org/10.1177/2041731418789838
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author Orapiriyakul, Wich
Young, Peter S
Damiati, Laila
Tsimbouri, Penelope M
author_facet Orapiriyakul, Wich
Young, Peter S
Damiati, Laila
Tsimbouri, Penelope M
author_sort Orapiriyakul, Wich
collection PubMed
description The use of biomaterials in orthopaedics for joint replacement, fracture healing and bone regeneration is a rapidly expanding field. Infection of these biomaterials is a major healthcare burden, leading to significant morbidity and mortality. Furthermore, the cost to healthcare systems is increasing dramatically. With advances in implant design and production, research has predominately focussed on osseointegration; however, modification of implant material, surface topography and chemistry can also provide antibacterial activity. With the increasing burden of infection, it is vitally important that we consider the bacterial interaction with the biomaterial and the host when designing and manufacturing future implants. During this review, we will elucidate the interaction between patient, biomaterial surface and bacteria. We aim to review current and developing surface modifications with a view towards antibacterial orthopaedic implants for clinical applications.
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spelling pubmed-60711642018-08-06 Antibacterial surface modification of titanium implants in orthopaedics Orapiriyakul, Wich Young, Peter S Damiati, Laila Tsimbouri, Penelope M J Tissue Eng Cell Engineering at the Micro/Nanoscale – Dedicated to Prof Adam Curtis The use of biomaterials in orthopaedics for joint replacement, fracture healing and bone regeneration is a rapidly expanding field. Infection of these biomaterials is a major healthcare burden, leading to significant morbidity and mortality. Furthermore, the cost to healthcare systems is increasing dramatically. With advances in implant design and production, research has predominately focussed on osseointegration; however, modification of implant material, surface topography and chemistry can also provide antibacterial activity. With the increasing burden of infection, it is vitally important that we consider the bacterial interaction with the biomaterial and the host when designing and manufacturing future implants. During this review, we will elucidate the interaction between patient, biomaterial surface and bacteria. We aim to review current and developing surface modifications with a view towards antibacterial orthopaedic implants for clinical applications. SAGE Publications 2018-07-25 /pmc/articles/PMC6071164/ /pubmed/30083308 http://dx.doi.org/10.1177/2041731418789838 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Cell Engineering at the Micro/Nanoscale – Dedicated to Prof Adam Curtis
Orapiriyakul, Wich
Young, Peter S
Damiati, Laila
Tsimbouri, Penelope M
Antibacterial surface modification of titanium implants in orthopaedics
title Antibacterial surface modification of titanium implants in orthopaedics
title_full Antibacterial surface modification of titanium implants in orthopaedics
title_fullStr Antibacterial surface modification of titanium implants in orthopaedics
title_full_unstemmed Antibacterial surface modification of titanium implants in orthopaedics
title_short Antibacterial surface modification of titanium implants in orthopaedics
title_sort antibacterial surface modification of titanium implants in orthopaedics
topic Cell Engineering at the Micro/Nanoscale – Dedicated to Prof Adam Curtis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071164/
https://www.ncbi.nlm.nih.gov/pubmed/30083308
http://dx.doi.org/10.1177/2041731418789838
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