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Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne

Chloracne is the major skin symptom caused by dioxin intoxication. Dioxin activates the aryl hydrocarbon receptor (AHR)–cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes leading to chloracne. Nuclear factor-erythroid 2-rel...

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Detalles Bibliográficos
Autores principales:	Furue, Masutaka, Fuyuno, Yoko, Mitoma, Chikage, Uchi, Hiroshi, Tsuji, Gaku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071176/ https://www.ncbi.nlm.nih.gov/pubmed/30011787 http://dx.doi.org/10.3390/antiox7070090

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