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Intestinal Barrier Function in Chronic Kidney Disease

The kidneys are key contributors to body homeostasis, by virtue of controlled excretion of excessive fluid, electrolytes, and toxic waste products. The syndrome of uremia equals the altered physiology due to irreversible loss of kidney function that is left uncorrected for, despite therapeutic inter...

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Autores principales: Meijers, Björn, Farré, Ricard, Dejongh, Sander, Vicario, Maria, Evenepoel, Pieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071212/
https://www.ncbi.nlm.nih.gov/pubmed/30029474
http://dx.doi.org/10.3390/toxins10070298
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author Meijers, Björn
Farré, Ricard
Dejongh, Sander
Vicario, Maria
Evenepoel, Pieter
author_facet Meijers, Björn
Farré, Ricard
Dejongh, Sander
Vicario, Maria
Evenepoel, Pieter
author_sort Meijers, Björn
collection PubMed
description The kidneys are key contributors to body homeostasis, by virtue of controlled excretion of excessive fluid, electrolytes, and toxic waste products. The syndrome of uremia equals the altered physiology due to irreversible loss of kidney function that is left uncorrected for, despite therapeutic intervention(s). The intestines and its microbial content are prime contributors to this syndrome. The intestinal barrier separates the self (or the so-called “milieu intérior”) from the environment. In the large intestine, the intestinal barrier keeps apart human physiology and the microbiota. The enterocytes and the extracellular mucin layer functions form a complex multilayered structure, facilitating complex bidirectional metabolic and immunological crosstalk. The current review focuses on the intestinal barrier in chronic kidney disease (CKD). Loss of kidney function results in structural and functional alterations of the intestinal barrier, contribution to the syndrome of uremia.
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spelling pubmed-60712122018-08-09 Intestinal Barrier Function in Chronic Kidney Disease Meijers, Björn Farré, Ricard Dejongh, Sander Vicario, Maria Evenepoel, Pieter Toxins (Basel) Review The kidneys are key contributors to body homeostasis, by virtue of controlled excretion of excessive fluid, electrolytes, and toxic waste products. The syndrome of uremia equals the altered physiology due to irreversible loss of kidney function that is left uncorrected for, despite therapeutic intervention(s). The intestines and its microbial content are prime contributors to this syndrome. The intestinal barrier separates the self (or the so-called “milieu intérior”) from the environment. In the large intestine, the intestinal barrier keeps apart human physiology and the microbiota. The enterocytes and the extracellular mucin layer functions form a complex multilayered structure, facilitating complex bidirectional metabolic and immunological crosstalk. The current review focuses on the intestinal barrier in chronic kidney disease (CKD). Loss of kidney function results in structural and functional alterations of the intestinal barrier, contribution to the syndrome of uremia. MDPI 2018-07-19 /pmc/articles/PMC6071212/ /pubmed/30029474 http://dx.doi.org/10.3390/toxins10070298 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Meijers, Björn
Farré, Ricard
Dejongh, Sander
Vicario, Maria
Evenepoel, Pieter
Intestinal Barrier Function in Chronic Kidney Disease
title Intestinal Barrier Function in Chronic Kidney Disease
title_full Intestinal Barrier Function in Chronic Kidney Disease
title_fullStr Intestinal Barrier Function in Chronic Kidney Disease
title_full_unstemmed Intestinal Barrier Function in Chronic Kidney Disease
title_short Intestinal Barrier Function in Chronic Kidney Disease
title_sort intestinal barrier function in chronic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071212/
https://www.ncbi.nlm.nih.gov/pubmed/30029474
http://dx.doi.org/10.3390/toxins10070298
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