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miRNAs in Insects Infected by Animal and Plant Viruses

Viruses vectored by insects cause severe medical and agricultural burdens. The process of virus infection of insects regulates and is regulated by a complex interplay of biomolecules including the small, non-coding microRNAs (miRNAs). Considered an anomaly upon its discovery only around 25 years ago...

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Autores principales: Monsanto-Hearne, Verna, Johnson, Karyn N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071220/
https://www.ncbi.nlm.nih.gov/pubmed/29970868
http://dx.doi.org/10.3390/v10070354
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author Monsanto-Hearne, Verna
Johnson, Karyn N.
author_facet Monsanto-Hearne, Verna
Johnson, Karyn N.
author_sort Monsanto-Hearne, Verna
collection PubMed
description Viruses vectored by insects cause severe medical and agricultural burdens. The process of virus infection of insects regulates and is regulated by a complex interplay of biomolecules including the small, non-coding microRNAs (miRNAs). Considered an anomaly upon its discovery only around 25 years ago, miRNAs as a class have challenged the molecular central dogma which essentially typifies RNAs as just intermediaries in the flow of information from DNA to protein. miRNAs are now known to be common modulators or fine-tuners of gene expression. While recent years has seen an increased emphasis on understanding the role of miRNAs in host-virus associations, existing literature on the interaction between insects and their arthropod-borne viruses (arboviruses) is largely restricted to miRNA abundance profiling. Here we analyse the commonalities and contrasts between miRNA abundance profiles with different host-arbovirus combinations and outline a suggested pipeline and criteria for functional analysis of the contribution of miRNAs to the insect vector-virus interaction. Finally, we discuss the potential use of the model organism, Drosophila melanogaster, in complementing research on the role of miRNAs in insect vector-virus interaction.
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spelling pubmed-60712202018-08-09 miRNAs in Insects Infected by Animal and Plant Viruses Monsanto-Hearne, Verna Johnson, Karyn N. Viruses Review Viruses vectored by insects cause severe medical and agricultural burdens. The process of virus infection of insects regulates and is regulated by a complex interplay of biomolecules including the small, non-coding microRNAs (miRNAs). Considered an anomaly upon its discovery only around 25 years ago, miRNAs as a class have challenged the molecular central dogma which essentially typifies RNAs as just intermediaries in the flow of information from DNA to protein. miRNAs are now known to be common modulators or fine-tuners of gene expression. While recent years has seen an increased emphasis on understanding the role of miRNAs in host-virus associations, existing literature on the interaction between insects and their arthropod-borne viruses (arboviruses) is largely restricted to miRNA abundance profiling. Here we analyse the commonalities and contrasts between miRNA abundance profiles with different host-arbovirus combinations and outline a suggested pipeline and criteria for functional analysis of the contribution of miRNAs to the insect vector-virus interaction. Finally, we discuss the potential use of the model organism, Drosophila melanogaster, in complementing research on the role of miRNAs in insect vector-virus interaction. MDPI 2018-07-03 /pmc/articles/PMC6071220/ /pubmed/29970868 http://dx.doi.org/10.3390/v10070354 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Monsanto-Hearne, Verna
Johnson, Karyn N.
miRNAs in Insects Infected by Animal and Plant Viruses
title miRNAs in Insects Infected by Animal and Plant Viruses
title_full miRNAs in Insects Infected by Animal and Plant Viruses
title_fullStr miRNAs in Insects Infected by Animal and Plant Viruses
title_full_unstemmed miRNAs in Insects Infected by Animal and Plant Viruses
title_short miRNAs in Insects Infected by Animal and Plant Viruses
title_sort mirnas in insects infected by animal and plant viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071220/
https://www.ncbi.nlm.nih.gov/pubmed/29970868
http://dx.doi.org/10.3390/v10070354
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