Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus

Neuraminidase is the main target for current influenza drugs. Reduced susceptibility to oseltamivir, the most widely prescribed neuraminidase inhibitor, has been repeatedly reported. The resistance substitutions I223V and S247N, alone or in combination with the major oseltamivir-resistance mutation...

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Detalles Bibliográficos
Autores principales: Pokorná, Jana, Pachl, Petr, Karlukova, Elena, Hejdánek, Jakub, Řezáčová, Pavlína, Machara, Aleš, Hudlický, Jason, Konvalinka, Jan, Kožíšek, Milan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071225/
https://www.ncbi.nlm.nih.gov/pubmed/29933553
http://dx.doi.org/10.3390/v10070339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071225/
https://www.ncbi.nlm.nih.gov/pubmed/29933553
http://dx.doi.org/10.3390/v10070339

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