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Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery
This paper develops theory for bulk acoustic streaming in soft porous materials, with applications to biological tissue. The principal results of this paper are: (i) streaming equations for such porous media, which show interestingly significant differences from those that describe streaming in pure...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071378/ https://www.ncbi.nlm.nih.gov/pubmed/30083324 http://dx.doi.org/10.1186/s40349-018-0114-6 |
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author | Raghavan, Raghu |
author_facet | Raghavan, Raghu |
author_sort | Raghavan, Raghu |
collection | PubMed |
description | This paper develops theory for bulk acoustic streaming in soft porous materials, with applications to biological tissue. The principal results of this paper are: (i) streaming equations for such porous media, which show interestingly significant differences from those that describe streaming in pure fluids; (ii) the Green functions obtained for these equations in isotropic, infinite media; and (iii) approximate evaluation of the sources in the streaming equations from acoustic wave forms often used, and the streaming velocities and particle trajectories resulting therefrom. People are now investigating acoustic enhancement of delivery of therapeutics such as drug molecules or other particulates, introduced directly into cellular tissue. A comparison of the predictions of the theory in this paper to available data is made and shown to be surprisingly good. Some macroscale effects of the ultrastructure of the tissue that are not contained in the current paper are pointed out for future studies. |
format | Online Article Text |
id | pubmed-6071378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60713782018-08-06 Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery Raghavan, Raghu J Ther Ultrasound Research This paper develops theory for bulk acoustic streaming in soft porous materials, with applications to biological tissue. The principal results of this paper are: (i) streaming equations for such porous media, which show interestingly significant differences from those that describe streaming in pure fluids; (ii) the Green functions obtained for these equations in isotropic, infinite media; and (iii) approximate evaluation of the sources in the streaming equations from acoustic wave forms often used, and the streaming velocities and particle trajectories resulting therefrom. People are now investigating acoustic enhancement of delivery of therapeutics such as drug molecules or other particulates, introduced directly into cellular tissue. A comparison of the predictions of the theory in this paper to available data is made and shown to be surprisingly good. Some macroscale effects of the ultrastructure of the tissue that are not contained in the current paper are pointed out for future studies. BioMed Central 2018-08-02 /pmc/articles/PMC6071378/ /pubmed/30083324 http://dx.doi.org/10.1186/s40349-018-0114-6 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Raghavan, Raghu Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery |
title | Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery |
title_full | Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery |
title_fullStr | Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery |
title_full_unstemmed | Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery |
title_short | Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery |
title_sort | theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071378/ https://www.ncbi.nlm.nih.gov/pubmed/30083324 http://dx.doi.org/10.1186/s40349-018-0114-6 |
work_keys_str_mv | AT raghavanraghu theoryforacousticstreaminginsoftporousmatteranditsapplicationstoultrasoundenhancedconvectivedelivery |