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EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization

BACKGROUND: Proliferating cell nuclear antigen (PCNA), a ring-shaped homotrimer complex, promotes DNA replication via binding to DNA polymerase. Trimerized PCNA is critical for DNA replication. Enhancer of zeste homologue 2 (EZH2), which primarily acts as a histone methyltransferase, is essential fo...

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Detalles Bibliográficos
Autores principales:	A, Peng, Xu, Xinyi, Wang, Chenglin, Yang, Jing, Wang, Shida, Dai, Jiewen, Ye, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071395/ https://www.ncbi.nlm.nih.gov/pubmed/30071900 http://dx.doi.org/10.1186/s13072-018-0213-1

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