Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine

Rationale: Pancreatic cancer is associated with poor prognosis with a 5-year survival rate of less than 6%. Approximately 90% of pancreatic cancer patients harbor somatic mutations in the KRAS gene. Multiple lines of evidence suggest a persistent activation of STAT3 in KRAS-driven oncogenesis contri...

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Detalles Bibliográficos
Autores principales: Lankadasari, Manendra Babu, Aparna, Jayasekharan S., Mohammed, Sabira, James, Shirley, Aoki, Kazunori, Binu, Valsalakumari S., Nair, Sindhu, Harikumar, Kuzhuvelil B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071521/
https://www.ncbi.nlm.nih.gov/pubmed/30083262
http://dx.doi.org/10.7150/thno.25308

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