Working memory deficit in drug-resistant epilepsy with an amygdala lesion

This study compared temporal lobe epilepsy (TLE) patients with amygdala lesion (AL) without hippocampal sclerosis (HS) (TLE-AL) with patients with TLE and HS without AL (TLE-HS). Both subtypes of TLE arose from the right hemisphere. The TLE-AL group exhibited a lower Working Memory Index (WMI) on th...

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Detalles Bibliográficos
Autores principales: Usui, Keiko, Terada, Kiyohito, Usui, Naotaka, Matsuda, Kazumi, Kondo, Akihiko, Tottori, Takayasu, Shinozaki, Jun, Nagamine, Takashi, Inoue, Yushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071582/
https://www.ncbi.nlm.nih.gov/pubmed/30094180
http://dx.doi.org/10.1016/j.ebcr.2018.07.003
Descripción
Sumario:This study compared temporal lobe epilepsy (TLE) patients with amygdala lesion (AL) without hippocampal sclerosis (HS) (TLE-AL) with patients with TLE and HS without AL (TLE-HS). Both subtypes of TLE arose from the right hemisphere. The TLE-AL group exhibited a lower Working Memory Index (WMI) on the Wechsler Adult Intelligence Scale, third edition (WAIS-III), indicating that the amygdala in the right hemisphere is involved in memory-related function. [18F]fluorodeoxyglucose positron emission topography (FDG-PET) showed glucose hypometabolism limited to the right uncus for the TLE-AL group. The results suggest the importance of considering cognitive functions in the non-dominant hemisphere to prevent impairment after surgery.

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