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On the Relationship Between High-Order Linkage Disequilibrium and Epistasis

A plausible explanation for statistical epistasis revealed in genome wide association analyses is the presence of high order linkage disequilibrium (LD) between the genotyped markers tested for interactions and unobserved functional polymorphisms. Based on findings in experimental data, it has been...

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Detalles Bibliográficos
Autores principales: Zan, Yanjun, Forsberg, Simon K. G., Carlborg, Örjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071592/
https://www.ncbi.nlm.nih.gov/pubmed/29945968
http://dx.doi.org/10.1534/g3.118.200513