Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors

Inhibitors of diacylglycerol lipases and α,β-hydrolase domain containing protein 6 (ABHD6) are potential leads for the development of therapeutic agents for metabolic and neurodegenerative disorders. Here, we report the enantioselective synthesis and structure activity relationships of triazole urea...

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Detalles Bibliográficos
Autores principales: Deng, Hui, van der Wel, Tom, van den Berg, Richard J. B. H. N., van den Nieuwendijk, Adrianus M. C. H., Janssen, Freek J., Baggelaar, Marc P., Overkleeft, Hermen S., van der Stelt, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071720/
https://www.ncbi.nlm.nih.gov/pubmed/30108813
http://dx.doi.org/10.1039/c7md00029d

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