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Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results(1)
Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total cholesterol (TC) have not shown significant mortality improvements. An inverse association of TC and LDL-C with all-cause...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Biochemistry and Molecular Biology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071781/ https://www.ncbi.nlm.nih.gov/pubmed/29895699 http://dx.doi.org/10.1194/jlr.P084277 |
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author | Kaysen, George A. Ye, Xiaoling Raimann, Jochen G. Wang, Yuedong Topping, Alice Usvyat, Len A. Stuard, Stefano Canaud, Bernard van der Sande, Frank M. Kooman, Jeroen P. Kotanko, Peter |
author_facet | Kaysen, George A. Ye, Xiaoling Raimann, Jochen G. Wang, Yuedong Topping, Alice Usvyat, Len A. Stuard, Stefano Canaud, Bernard van der Sande, Frank M. Kooman, Jeroen P. Kotanko, Peter |
author_sort | Kaysen, George A. |
collection | PubMed |
description | Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total cholesterol (TC) have not shown significant mortality improvements. An inverse association of TC and LDL-C with all-cause and CV mortality has been observed in patients on chronic dialysis. Lipoproteins also may protect against infectious diseases. We used data from 37,250 patients in the international Monitoring Dialysis Outcomes (MONDO) database to evaluate the association between lipids and infection-related or CV mortality. The study began on the first day of lipid measurement and continued for up to 4 years. We applied Cox proportional models with time-varying covariates to study associations of LDL-C, HDL cholesterol (HDL-C), and triglycerides (TGs) with all-cause, CV, infectious, and other causes of death. Overall, 6,147 patients died (19.2% from CV, 13.2% from infection, and 67.6% from other causes). After multivariable adjustment, higher LDL-C, HDL-C, and TGs were independently associated with lower all-cause death risk. Neither LDL-C nor TGs were associated with CV death, and HDL-C was associated with lower CV risk. Higher LDL-C and HDL-C were associated with a lower risk of death from infection or other non-CV causes. LDL-C was associated with reduced all-cause and infectious, but not CV mortality, which resulted in the inverse association with all-cause mortality. |
format | Online Article Text |
id | pubmed-6071781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-60717812018-08-06 Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results(1) Kaysen, George A. Ye, Xiaoling Raimann, Jochen G. Wang, Yuedong Topping, Alice Usvyat, Len A. Stuard, Stefano Canaud, Bernard van der Sande, Frank M. Kooman, Jeroen P. Kotanko, Peter J Lipid Res Patient-Oriented and Epidemiological Research Cardiovascular (CV) events are increased 36-fold in patients with end-stage renal disease. However, randomized controlled trials to lower LDL cholesterol (LDL-C) and serum total cholesterol (TC) have not shown significant mortality improvements. An inverse association of TC and LDL-C with all-cause and CV mortality has been observed in patients on chronic dialysis. Lipoproteins also may protect against infectious diseases. We used data from 37,250 patients in the international Monitoring Dialysis Outcomes (MONDO) database to evaluate the association between lipids and infection-related or CV mortality. The study began on the first day of lipid measurement and continued for up to 4 years. We applied Cox proportional models with time-varying covariates to study associations of LDL-C, HDL cholesterol (HDL-C), and triglycerides (TGs) with all-cause, CV, infectious, and other causes of death. Overall, 6,147 patients died (19.2% from CV, 13.2% from infection, and 67.6% from other causes). After multivariable adjustment, higher LDL-C, HDL-C, and TGs were independently associated with lower all-cause death risk. Neither LDL-C nor TGs were associated with CV death, and HDL-C was associated with lower CV risk. Higher LDL-C and HDL-C were associated with a lower risk of death from infection or other non-CV causes. LDL-C was associated with reduced all-cause and infectious, but not CV mortality, which resulted in the inverse association with all-cause mortality. The American Society for Biochemistry and Molecular Biology 2018-08 2018-06-12 /pmc/articles/PMC6071781/ /pubmed/29895699 http://dx.doi.org/10.1194/jlr.P084277 Text en Copyright © 2018 Kaysen et al. Published by The American Society for Biochemistry and Molecular Biology, Inc. http://creativecommons.org/licenses/by/4.0/ Author’s Choice—Final version open access under the terms of the Creative Commons CC-BY license. |
spellingShingle | Patient-Oriented and Epidemiological Research Kaysen, George A. Ye, Xiaoling Raimann, Jochen G. Wang, Yuedong Topping, Alice Usvyat, Len A. Stuard, Stefano Canaud, Bernard van der Sande, Frank M. Kooman, Jeroen P. Kotanko, Peter Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results(1) |
title | Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results(1) |
title_full | Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results(1) |
title_fullStr | Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results(1) |
title_full_unstemmed | Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results(1) |
title_short | Lipid levels are inversely associated with infectious and all-cause mortality: international MONDO study results(1) |
title_sort | lipid levels are inversely associated with infectious and all-cause mortality: international mondo study results(1) |
topic | Patient-Oriented and Epidemiological Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071781/ https://www.ncbi.nlm.nih.gov/pubmed/29895699 http://dx.doi.org/10.1194/jlr.P084277 |
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