Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type–Specific Enhancer Activation and Gene Expression

BACKGROUND: Cigarette smoke is a causal factor in cancers and cardiovascular disease. Smoking-associated differentially methylated regions (SM-DMRs) have been observed in disease studies, but the causal link between altered DNA methylation and transcriptional change is obscure. OBJECTIVE: Our object...

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Detalles Bibliográficos
Autores principales: Wan, Ma, Bennett, Brian D., Pittman, Gary S., Campbell, Michelle R., Reynolds, Lindsay M., Porter, Devin K., Crowl, Christopher L., Wang, Xuting, Su, Dan, Englert, Neal A., Thompson, Isabel J., Liu, Yongmei, Bell, Douglas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071796/
https://www.ncbi.nlm.nih.gov/pubmed/29706059
http://dx.doi.org/10.1289/EHP2395

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