Diazabicyclo analogues of maraviroc: synthesis, modeling, NMR studies and antiviral activity

Two diazabicyclo analogues of maraviroc, in which the azabicyclooctane moiety is replaced by diazabicyclooctane or diazabicyclononane, were synthesized and tested, through a viral neutralization assay, on a panel of six pseudoviruses. The diazabicyclooctane derivative maintained a significant infect...

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Detalles Bibliográficos
Autores principales: Legnani, L., Colombo, D., Venuti, A., Pastori, C., Lopalco, L., Toma, L., Mori, M., Grazioso, G., Villa, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071814/
https://www.ncbi.nlm.nih.gov/pubmed/30108760
http://dx.doi.org/10.1039/c6md00575f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071814/
https://www.ncbi.nlm.nih.gov/pubmed/30108760
http://dx.doi.org/10.1039/c6md00575f

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