CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

The observation that BRCA1- and BRCA2-deficient cells are sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors spurred their development into cancer therapies that target homologous recombination (HR) deficiency1. The cytotoxicity of PARP inhibitors depends on PARP trapping, the formation of n...

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Detalles Bibliográficos
Autores principales: Zimmermann, Michal, Murina, Olga, Reijns, Martin A. M., Agathanggelou, Angelo, Challis, Rachel, Tarnauskaitė, Žygimantė, Muir, Morwenna, Fluteau, Adeline, Aregger, Michael, McEwan, Andrea, Yuan, Wei, Clarke, Matthew, Lambros, Maryou B., Paneesha, Shankara, Moss, Paul, Chandrashekhar, Megha, Angers, Stephane, Moffat, Jason, Brunton, Valerie G., Hart, Traver, de Bono, Johann, Stankovic, Tatjana, Jackson, Andrew P., Durocher, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071917/
https://www.ncbi.nlm.nih.gov/pubmed/29973717
http://dx.doi.org/10.1038/s41586-018-0291-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071917/
https://www.ncbi.nlm.nih.gov/pubmed/29973717
http://dx.doi.org/10.1038/s41586-018-0291-z

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