Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production

The production of envelope glycoproteins (Envs) for use as HIV vaccines is challenging. The yield of Envs expressed in stable Chinese Hamster Ovary (CHO) cell lines is typically 10–100 fold lower than other glycoproteins of pharmaceutical interest. Moreover, Envs produced in CHO cells are typically...

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Detalles Bibliográficos
Autores principales: O’Rourke, Sara M., Byrne, Gabriel, Tatsuno, Gwen, Wright, Meredith, Yu, Bin, Mesa, Kathryn A., Doran, Rachel C., Alexander, David, Berman, Phillip W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071959/
https://www.ncbi.nlm.nih.gov/pubmed/30071025
http://dx.doi.org/10.1371/journal.pone.0197656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071959/
https://www.ncbi.nlm.nih.gov/pubmed/30071025
http://dx.doi.org/10.1371/journal.pone.0197656

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