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Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children
BACKGROUND: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment. OBJECTIVE: Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Environmental Health Perspectives
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072011/ https://www.ncbi.nlm.nih.gov/pubmed/29727133 http://dx.doi.org/10.1289/EHP2777 |
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author | Jackson-Browne, Medina S. Papandonatos, George D. Chen, Aimin Calafat, Antonia M. Yolton, Kimberly Lanphear, Bruce P. Braun, Joseph M. |
author_facet | Jackson-Browne, Medina S. Papandonatos, George D. Chen, Aimin Calafat, Antonia M. Yolton, Kimberly Lanphear, Bruce P. Braun, Joseph M. |
author_sort | Jackson-Browne, Medina S. |
collection | PubMed |
description | BACKGROUND: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment. OBJECTIVE: Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study. METHODS: We quantified triclosan in urine samples from mother–child pairs up to nine times between the second trimester of gestation and 8 y of age. The Wechsler Intelligence Scale for Children-IV [i.e., Full-Scale Intelligence Quotient (IQ)] assessment was administered to HOME Study children at 8 y of age. We estimated covariate-adjusted triclosan–IQ associations at each visit. We also tested whether associations between triclosan concentrations and cognitive test scores varied among exposure at different time periods. RESULTS: Full-Scale IQ was not significantly associated with urinary triclosan concentrations during gestation or childhood but was significantly associated with a 10-fold increase in maternal urinary triclosan concentration at delivery [[Formula: see text] (95% CI: [Formula: see text] , [Formula: see text])]. Perceptual Reasoning Index (PRI) scores were significantly decreased in association with urinary triclosan concentrations at delivery and at 2 y of age. Associations between repeated triclosan concentrations and cognitive test scores significantly varied among exposure at different time periods for Full-Scale IQ, PRI, Verbal Comprehension Index, and Working Memory (triclosan–visit interaction [Formula: see text]). CONCLUSION: Urinary triclosan concentrations at delivery, but not during mid to late pregnancy and childhood, were associated with significantly lower children’s cognitive test scores at 8 y of age in this cohort of U.S. children. https://doi.org/10.1289/EHP2777 |
format | Online Article Text |
id | pubmed-6072011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Environmental Health Perspectives |
record_format | MEDLINE/PubMed |
spelling | pubmed-60720112018-08-09 Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children Jackson-Browne, Medina S. Papandonatos, George D. Chen, Aimin Calafat, Antonia M. Yolton, Kimberly Lanphear, Bruce P. Braun, Joseph M. Environ Health Perspect Research BACKGROUND: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment. OBJECTIVE: Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study. METHODS: We quantified triclosan in urine samples from mother–child pairs up to nine times between the second trimester of gestation and 8 y of age. The Wechsler Intelligence Scale for Children-IV [i.e., Full-Scale Intelligence Quotient (IQ)] assessment was administered to HOME Study children at 8 y of age. We estimated covariate-adjusted triclosan–IQ associations at each visit. We also tested whether associations between triclosan concentrations and cognitive test scores varied among exposure at different time periods. RESULTS: Full-Scale IQ was not significantly associated with urinary triclosan concentrations during gestation or childhood but was significantly associated with a 10-fold increase in maternal urinary triclosan concentration at delivery [[Formula: see text] (95% CI: [Formula: see text] , [Formula: see text])]. Perceptual Reasoning Index (PRI) scores were significantly decreased in association with urinary triclosan concentrations at delivery and at 2 y of age. Associations between repeated triclosan concentrations and cognitive test scores significantly varied among exposure at different time periods for Full-Scale IQ, PRI, Verbal Comprehension Index, and Working Memory (triclosan–visit interaction [Formula: see text]). CONCLUSION: Urinary triclosan concentrations at delivery, but not during mid to late pregnancy and childhood, were associated with significantly lower children’s cognitive test scores at 8 y of age in this cohort of U.S. children. https://doi.org/10.1289/EHP2777 Environmental Health Perspectives 2018-05-02 /pmc/articles/PMC6072011/ /pubmed/29727133 http://dx.doi.org/10.1289/EHP2777 Text en EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. |
spellingShingle | Research Jackson-Browne, Medina S. Papandonatos, George D. Chen, Aimin Calafat, Antonia M. Yolton, Kimberly Lanphear, Bruce P. Braun, Joseph M. Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children |
title | Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children |
title_full | Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children |
title_fullStr | Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children |
title_full_unstemmed | Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children |
title_short | Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children |
title_sort | identifying vulnerable periods of neurotoxicity to triclosan exposure in children |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072011/ https://www.ncbi.nlm.nih.gov/pubmed/29727133 http://dx.doi.org/10.1289/EHP2777 |
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