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Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy
BACKGROUND: For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date,...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072022/ https://www.ncbi.nlm.nih.gov/pubmed/30071042 http://dx.doi.org/10.1371/journal.pone.0201371 |
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author | Ostuzzi, Giovanni Mazzi, Maria Angela Terlizzi, Samira Bertolini, Federico Aguglia, Andrea Bartoli, Francesco Bortolaso, Paola Callegari, Camilla Caroleo, Mariarita Carrà, Giuseppe Corbo, Mariangela D’Agostino, Armando Gastaldon, Chiara Lucii, Claudio Magliocco, Fabio Martinotti, Giovanni Nosé, Michela Ostinelli, Edoardo Giuseppe Papola, Davide Piccinelli, Marco Piero Piccoli, Alberto Purgato, Marianna Tabacchi, Tommaso Turrini, Giulia Ruggeri, Mirella Barbui, Corrado |
author_facet | Ostuzzi, Giovanni Mazzi, Maria Angela Terlizzi, Samira Bertolini, Federico Aguglia, Andrea Bartoli, Francesco Bortolaso, Paola Callegari, Camilla Caroleo, Mariarita Carrà, Giuseppe Corbo, Mariangela D’Agostino, Armando Gastaldon, Chiara Lucii, Claudio Magliocco, Fabio Martinotti, Giovanni Nosé, Michela Ostinelli, Edoardo Giuseppe Papola, Davide Piccinelli, Marco Piero Piccoli, Alberto Purgato, Marianna Tabacchi, Tommaso Turrini, Giulia Ruggeri, Mirella Barbui, Corrado |
author_sort | Ostuzzi, Giovanni |
collection | PubMed |
description | BACKGROUND: For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. METHODS: The STAR Network “Depot” Study is an observational, longitudinal, multicenter study involving 35 centers in Italy. In the cross-sectional phase, patients prescribed with LAIs were consecutively recruited and assessed over a period of 12 months. Descriptive statistics and multivariable logistic regression analyses were employed. RESULTS: Of the 451 recruited patients, 61% were males. The level of social and working functioning was heterogeneous, as was the severity of disease. Seventy-two per cent of the patients had a diagnosis of the schizophrenia spectrum. Seventy per cent were prescribed with second-generation antipsychotic (SGA) LAIs (mostly paliperidone, aripiprazole and risperidone). Compared to first-generation antipsychotic (FGA) LAIs, patients prescribed with SGA LAIs were more often younger; employed; with a diagnosis of the schizophrenia spectrum or bipolar disorder; with higher levels of affective symptoms; with fewer LAI prescriptions in the past. DISCUSSION: LAIs’ prescribing practices appear to be more flexible as compared to the past, although this change is mostly restricted to SGA LAIs. |
format | Online Article Text |
id | pubmed-6072022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-60720222018-08-16 Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy Ostuzzi, Giovanni Mazzi, Maria Angela Terlizzi, Samira Bertolini, Federico Aguglia, Andrea Bartoli, Francesco Bortolaso, Paola Callegari, Camilla Caroleo, Mariarita Carrà, Giuseppe Corbo, Mariangela D’Agostino, Armando Gastaldon, Chiara Lucii, Claudio Magliocco, Fabio Martinotti, Giovanni Nosé, Michela Ostinelli, Edoardo Giuseppe Papola, Davide Piccinelli, Marco Piero Piccoli, Alberto Purgato, Marianna Tabacchi, Tommaso Turrini, Giulia Ruggeri, Mirella Barbui, Corrado PLoS One Research Article BACKGROUND: For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. METHODS: The STAR Network “Depot” Study is an observational, longitudinal, multicenter study involving 35 centers in Italy. In the cross-sectional phase, patients prescribed with LAIs were consecutively recruited and assessed over a period of 12 months. Descriptive statistics and multivariable logistic regression analyses were employed. RESULTS: Of the 451 recruited patients, 61% were males. The level of social and working functioning was heterogeneous, as was the severity of disease. Seventy-two per cent of the patients had a diagnosis of the schizophrenia spectrum. Seventy per cent were prescribed with second-generation antipsychotic (SGA) LAIs (mostly paliperidone, aripiprazole and risperidone). Compared to first-generation antipsychotic (FGA) LAIs, patients prescribed with SGA LAIs were more often younger; employed; with a diagnosis of the schizophrenia spectrum or bipolar disorder; with higher levels of affective symptoms; with fewer LAI prescriptions in the past. DISCUSSION: LAIs’ prescribing practices appear to be more flexible as compared to the past, although this change is mostly restricted to SGA LAIs. Public Library of Science 2018-08-02 /pmc/articles/PMC6072022/ /pubmed/30071042 http://dx.doi.org/10.1371/journal.pone.0201371 Text en © 2018 Ostuzzi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ostuzzi, Giovanni Mazzi, Maria Angela Terlizzi, Samira Bertolini, Federico Aguglia, Andrea Bartoli, Francesco Bortolaso, Paola Callegari, Camilla Caroleo, Mariarita Carrà, Giuseppe Corbo, Mariangela D’Agostino, Armando Gastaldon, Chiara Lucii, Claudio Magliocco, Fabio Martinotti, Giovanni Nosé, Michela Ostinelli, Edoardo Giuseppe Papola, Davide Piccinelli, Marco Piero Piccoli, Alberto Purgato, Marianna Tabacchi, Tommaso Turrini, Giulia Ruggeri, Mirella Barbui, Corrado Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy |
title | Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy |
title_full | Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy |
title_fullStr | Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy |
title_full_unstemmed | Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy |
title_short | Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy |
title_sort | factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in italy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072022/ https://www.ncbi.nlm.nih.gov/pubmed/30071042 http://dx.doi.org/10.1371/journal.pone.0201371 |
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